Gastroenterology and Hepatology, Regions Hospital, Saint Paul, Minnesota, USA
Department of Gastroenterology and Hepatology, University of Minnesota System, Minneapolis, Minnesota, USA.
BMJ Case Rep. 2021 May 25;14(5):e240226. doi: 10.1136/bcr-2020-240226.
Amyloidosis constitutes a heterogeneous group of disorders of protein misfolding that can involve different organ systems. The disease can occur either in a systemic or localised manner that is well known to involve the gastrointestinal (GI) tract. GI amyloidosis can present with a wide range of symptoms including diarrhoea, bleeding and obstruction. This case illustrates a patient with localised jejunal amyloid light chain disease that was diagnosed serendipitously during a workup for haematuria. Our patient was otherwise asymptomatic, but this case underscores the importance of considering amyloidosis as a possible cause of isolated masses of the small intestine.
淀粉样变性是一组由蛋白质错误折叠引起的异质性疾病,可累及不同的器官系统。该疾病可以全身性或局限性方式发生,众所周知,胃肠道(GI)也会受到累及。GI 淀粉样变性可引起多种症状,包括腹泻、出血和梗阻。本病例介绍了一位局限于空肠的轻链淀粉样变性患者,他是在因血尿进行检查时偶然被诊断出来的。患者除此以外无症状,但该病例强调了将淀粉样变性作为孤立性小肠肿块的可能病因进行考虑的重要性。