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通过机械化学亚磷酰胺化学合成核苷酸二聚体的研究。

Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry.

作者信息

Johnston C, Hardacre C, Migaud M E

机构信息

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Northern Ireland, UK.

The Mill, Sackville Street Campus, University of Manchester, Manchester, UK.

出版信息

R Soc Open Sci. 2021 Mar 31;8(3):201703. doi: 10.1098/rsos.201703.

DOI:10.1098/rsos.201703
PMID:34035937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8101013/
Abstract

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5'-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.

摘要

已对液体辅助机械化学作为一种将亚磷酰胺核苷与5'-OH部分保护的核苷偶联的通用方法进行了研究。与已报道的方法相比，其显著优点包括反应方案简化、有毒溶剂使用量大幅减少、通过改进固体试剂混合促进机械化学反应以及水解产物生成量低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/6f85278088d4/rsos201703f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/789a24bad536/rsos201703f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/b04f91003c4e/rsos201703f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/0df7186d1975/rsos201703f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/72b00f82e738/rsos201703f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/100496a9abff/rsos201703f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/6f85278088d4/rsos201703f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/789a24bad536/rsos201703f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/b04f91003c4e/rsos201703f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/0df7186d1975/rsos201703f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/72b00f82e738/rsos201703f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/100496a9abff/rsos201703f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d80b/8101013/6f85278088d4/rsos201703f06.jpg

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本文引用的文献

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2
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Structural and infrared spectroscopic studies of some novel mechanochemically accessed adducts of silver(I) oxoanion salts with thiourea.一些新型银（I）含氧阴离子盐与硫脲通过机械化学方法得到的加合物的结构和红外光谱研究。
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