Casanova Joao, Cunha José Filipe
Gynecologic Oncology Unit, Centro Clínico Champalimaud, Lisbon, Portugal.
Digestive Surgery Unit, Centro Clínico Champalimaud, Lisbon, Portugal.
Gynecol Oncol Rep. 2021 May 7;36:100781. doi: 10.1016/j.gore.2021.100781. eCollection 2021 May.
Upfront debulking surgery followed by adjuvant chemotherapy still remains as the mainstay approach to patients with advanced ovarian cancer (Eisenhauer et al., 2006). Upper abdominal surgery is often required to achieve complete gross resection and there are several studies in the literature reporting increased survival, as well as a minimal but acceptable increase in morbidity, as a result of this shift in the surgical paradigm (Chi et al., 2009). Cardiophrenic lymph nodes (CPLNs), also referred to as paracardiac and supradiaphragmatic lymph nodes, are located just above the diaphragm. In diseases such as advanced ovarian cancer, where there is often considerable abdominal and peritoneal tumor burden, these lymph nodes can harbor metastases. These nodes are usually larger than 5 mm in diameter and are easily identified on computed tomography. Evidence suggests that this finding should not preclude primary debulking surgery (if resectable disease in the abdomen) as it is associated with an increased median overall survival even in stage IV disease (Cowan et al., 2017, Prader et al., 2016). We present a video highlighting one of the most commonly performed debulking procedures in the upper abdomen - right diaphragmatic peritoneal stripping (the patient had multiple small implants in both the diaphragmatic peritoneum and Morisońs Pouch peritoneum, so en bloc resection was performed) - followed by a transabdominal excision of an enlarged right cardiophrenic lymph node. The defect was closed with a 2-0 polypropylene running suture.
对于晚期卵巢癌患者, upfront 减瘤手术联合辅助化疗仍然是主要的治疗方法(Eisenhauer等人,2006年)。通常需要进行上腹部手术以实现肉眼完全切除,并且文献中有多项研究报告称,由于手术模式的这种转变,生存率提高,同时发病率虽有小幅但可接受的增加(Chi等人,2009年)。心膈淋巴结(CPLNs),也称为心旁淋巴结和膈上淋巴结,位于膈肌上方。在晚期卵巢癌等疾病中,腹部和腹膜肿瘤负荷通常较大,这些淋巴结可能会发生转移。这些淋巴结直径通常大于5毫米,在计算机断层扫描上很容易识别。有证据表明,这一发现不应排除初次减瘤手术(如果腹部疾病可切除),因为即使在IV期疾病中,它也与中位总生存期的增加相关(Cowan等人,2017年,Prader等人,2016年)。我们展示了一段视频,重点介绍了上腹部最常进行的减瘤手术之一——右膈肌腹膜剥脱术(患者膈肌腹膜和莫里森囊腹膜均有多个小种植灶,因此进行了整块切除),随后经腹切除一个肿大的右心膈淋巴结。缺损用2-0聚丙烯连续缝合线缝合。