Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Otafuku Sauce Co., Ltd., Hiroshima, Japan.
Biosci Biotechnol Biochem. 2021 Jun 24;85(7):1753-1758. doi: 10.1093/bbb/zbab093.
An extract of date (fruit of a palm tree) residue plus food-grade glutamate, acetic acid, and yeast extract (date residue extract mix, DREM) has been successfully fermented with using Lactobacillus brevis JCM 1059T to produce gamma-aminobutyric acid (GABA). Here, mouse splenocytes were found to be viable when supplemented with DREM and fermented DREM containing GABA (fDREM). The addition of DREM and fDREM resulted in the secretion of tumor necrosis factor (TNF)-α from the splenocytes, fDREM being more effective than DREM. The TNF-α secretion with DREM was elevated by exogenous addition of GABA and that with fDREM was in part mediated via A-type GABA receptors. Contrary to general understanding of the suppressive effects of GABA on various biological functions, our findings suggest that GABA-containing fDREM arguments the immune function as a food and pharmaceutical material.
一种由椰枣（棕榈树的果实）残渣加上食品级谷氨酸、乙酸和酵母提取物（椰枣残渣提取物混合物，DREM）制成的提取物，已成功地使用短乳杆菌 JCM 1059T 发酵生产出γ-氨基丁酸（GABA）。在这里，当用 DREM 和含有 GABA 的发酵 DREM（fDREM）补充时，发现小鼠脾细胞是有活力的。添加 DREM 和 fDREM 导致 TNF-α从脾细胞中分泌，fDREM 比 DREM 更有效。通过外源性添加 GABA 可提高 DREM 的 TNF-α 分泌，而 fDREM 的部分作用则通过 A 型 GABA 受体介导。与 GABA 对各种生物功能的抑制作用的一般理解相反，我们的发现表明，含有 GABA 的 fDREM 作为食品和医药材料可以增强免疫功能。
