晚期血吸虫病患者循环 Vδ1 γδT 细胞频率升高。

Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis.

机构信息

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Key Laboratory of Parasite and Vector Biology, National Health Commission of People's Republic of China, WHO Collaborating Center for Tropical Diseases, Shanghai, China.

Hubei Provincial Center for Disease Control and Prevention, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Key Laboratory for Applied Toxicology, Wuhan, China.

出版信息

Parasite Immunol. 2021 Oct;43(10-11):e12871. doi: 10.1111/pim.12871. Epub 2021 Jul 21.

DOI:10.1111/pim.12871

PMID:34037255

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9285544/

Abstract

Gamma-delta (γδ) T cells are the bridge between natural and adaptive immunity. In the present study, peripheral blood was collected from 13 patients with advanced schistosomiasis (schistosomiasis group) and 13 uninfected people (control group) to investigate the γδ T cells and their subtypes in human schistosomiasis. Compared with the control group, the proportion of Vδ1 cells and CD27 Vδ1 cells in the schistosomiasis group increased significantly, while CD27 cells and CD27 Vδ1 cells decreased. Only the level of IL-17A differed between the groups, being significantly decreased in the schistosomiasis group. In the schistosomiasis group, there were no correlations between the liver fibrosis and subsets of γδ T cells, or the level of cytokines. Additionally, the level of IL-17A correlated positively with the proportion of CD27 Vδ1 cells. Thus, there was a higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis. The decreased IL-17A might be related to the reduction in CD27 Vδ1 cell.

摘要

γδ（γδ）T 细胞是天然免疫和适应性免疫之间的桥梁。在本研究中，采集了 13 例晚期血吸虫病患者（血吸虫病组）和 13 例未感染人群（对照组）的外周血，以研究人类血吸虫病中的γδ T 细胞及其亚群。与对照组相比，血吸虫病组中 Vδ1 细胞和 CD27 Vδ1 细胞的比例显著增加，而 CD27 细胞和 CD27 Vδ1 细胞减少。仅细胞因子 IL-17A 在两组之间存在差异，在血吸虫病组中显著降低。在血吸虫病组中，γδ T 细胞亚群与肝纤维化程度或细胞因子水平之间无相关性。此外，IL-17A 水平与 CD27 Vδ1 细胞比例呈正相关。因此，晚期血吸虫病患者循环中 Vδ1 γδT 细胞的频率较高。IL-17A 的减少可能与 CD27 Vδ1 细胞的减少有关。