Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, China.
Department of Head & Neck Surgery, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, China.
Biomark Med. 2021 Jun;15(9):615-622. doi: 10.2217/bmm-2020-0418. Epub 2021 May 26.
Hepatocellular carcinoma (HCC) is considered to be the third leading cause of cancer death. The homologous gene of TP53 is significant in the occurrence and development of cancer. This study explored the relationship between TP53 rs28934571 polymorphism and HCC risk in Guangxi, China. We first screened the association through bioinformatics. Additionally, a case-control study was performed to further verify the relationship between gene polymorphism and HCC risk after collecting clinical characteristics. Results showed that allele A on TP53 rs28934571 was a risk factor for HCC and mutation from C to A on TP53 rs28934571 would increase the risk of poor prognosis of HCC. Therefore, the study concluded that TP53 rs28934571 may become a diagnostic indicator in judging the prognosis of HCC.
肝细胞癌（HCC）被认为是癌症死亡的第三大主要原因。TP53 同源基因在癌症的发生和发展中具有重要意义。本研究探讨了 TP53 rs28934571 多态性与中国广西 HCC 风险之间的关系。我们首先通过生物信息学筛选了关联。此外，在收集临床特征后，进行了病例对照研究以进一步验证基因多态性与 HCC 风险之间的关系。结果表明，TP53 rs28934571 上的等位基因 A 是 HCC 的危险因素，并且 TP53 rs28934571 上从 C 到 A 的突变会增加 HCC 预后不良的风险。因此，该研究得出结论，TP53 rs28934571 可能成为判断 HCC 预后的诊断指标。
