5-氟尿嘧啶的心肌毒性
Myocardiotoxicity of 5 fluorouracil.
作者信息
Coronel B, Madonna O, Mercatello A, Caillette A, Moskovtchenko J F
机构信息
Département de Néphrologie, Hôpital Edouard Herriot, Lyon, France.
出版信息
Intensive Care Med. 1988;14(4):429-30. doi: 10.1007/BF00262901.
We report a case of specific myocardiotoxicity due to 5 F.U. not previously described in man. A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U. and cis-platinum. Dopamine was necessary to maintain blood pressure. Two-D echocardiography and a right heart catheterisation confirmed the alteration of myocardial contractility. After 2 weeks a complete cardiac recovery occurred.
我们报告了一例由5-氟尿嘧啶引起的特定心肌毒性病例，此前在人类中未见报道。一名41岁男性因心脏和肾衰竭入住重症监护病房，在接受5-氟尿嘧啶和顺铂治疗5天后24小时出现症状。需要使用多巴胺来维持血压。二维超声心动图和右心导管检查证实了心肌收缩力的改变。两周后心脏完全恢复。
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