Department of Hematology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
J Int Med Res. 2021 May;49(5):3000605211016138. doi: 10.1177/03000605211016138.
Acute myeloid leukemia (AML) with T lymphoblastic lymphoma (T-LBL) is a hematologic tumor of two origins, myeloid and lymphoblastic, and is relatively rare in the same patient. We report a rare case of AML with T-LBL. After the patient was diagnosed, he received standard chemotherapy, which decreased the primitive bone marrow cell percentage from 84% to 5%; however, the enlarged superficial lymph nodes showed no obvious change in size. Immunohistochemistry revealed the following: cluster of differentiation (CD)3 (+), CD5 (+), CD7 (+), transmission disequilibrium test (TDT) (+), myeloperoxidase (MPO) (-), and lysozyme (Lys) (-). The lymph node morphology and immunohistochemical results indicated T-LBL. Therefore, the final diagnosis was AML with T-LBL, with both diseases occurring independently and concurrently.
急性髓系白血病(AML)伴 T 淋巴母细胞淋巴瘤(T-LBL)是一种起源于髓系和淋巴母细胞的血液系统肿瘤,在同一患者中较为罕见。我们报告一例 AML 伴 T-LBL 的罕见病例。患者确诊后接受了标准化疗,原始骨髓细胞百分比从 84%降至 5%;然而,肿大的浅表淋巴结大小无明显变化。免疫组化显示:分化群(CD)3(+)、CD5(+)、CD7(+)、传递不平衡试验(TDT)(+)、髓过氧化物酶(MPO)(-)和溶菌酶(Lys)(-)。淋巴结形态学和免疫组化结果提示 T-LBL。因此,最终诊断为 AML 伴 T-LBL,两种疾病独立发生且同时存在。