孤立性脾结核在中期氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描中伪装成霍奇金淋巴瘤的疾病进展

Isolated Splenic Tuberculosis Masquerading as Disease Progression of Hodgkin's Lymphoma on InterimF-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan.

作者信息

Dey Sudip, Gupta Nitin, Verma Ritu, Seniaray Nikhil, Belho Ethel Shangne, Dhawan Shashi

机构信息

Department of Nuclear Medicine, Mahajan Imaging, Sir Gangaram Hospital, New Delhi, India.

Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India.

出版信息

Indian J Nucl Med. 2021 Jan-Mar;36(1):100-102. doi: 10.4103/ijnm.IJNM_145_20. Epub 2021 Mar 4.

DOI:10.4103/ijnm.IJNM_145_20

PMID:34040315

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8130692/

Abstract

F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) scan is the imaging modality of choice in the management of lymphoma. However, 18F-FDG is a nonspecific tracer for tumoral metabolic activity and infective pathology, thus posing a challenge in accurate response assessment. Here, we present a case of Hodgkin's lymphoma, referred for staging PET/CT scan which showed FDG-avid disease in the mediastinum, and on interim F-FDG PET/CT in addition to the mediastinal mass lesion, a FDG-avid lesion was also noted in the spleen suggestive of disease progression. The biopsy report of the lesion was tuberculosis, which was masquerading as disease progression on interim F-FDG PET/CT.

摘要

氟脱氧葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）是淋巴瘤管理中的首选成像方式。然而，18F-FDG是肿瘤代谢活性和感染性病理的非特异性示踪剂，因此在准确的反应评估中构成挑战。在此，我们报告一例霍奇金淋巴瘤病例，该病例因分期PET/CT扫描前来就诊，扫描显示纵隔有FDG摄取阳性病变，而在中期F-FDG PET/CT检查中，除纵隔肿块病变外，脾脏还发现一个FDG摄取阳性病变，提示疾病进展。病变的活检报告为结核病，在中期F-FDG PET/CT上表现为疾病进展的假象。