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将应激反应机制应用于工业领域。

Leveraging Stress Response Mechanisms for Industrial Applications.

作者信息

Craig Kelly, Johnson Brant R, Grunden Amy

机构信息

AgBiome Inc., Research Triangle Park, NC, United States.

Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, United States.

出版信息

Front Microbiol. 2021 May 10;12:660134. doi: 10.3389/fmicb.2021.660134. eCollection 2021.

Abstract

Members of the genus are metabolically versatile and capable of adapting to a wide variety of environments. Stress physiology of strains has been extensively studied because of their biotechnological potential in agriculture as well as their medical importance with regards to pathogenicity and antibiotic resistance. This versatility and scientific relevance led to a substantial amount of information regarding the stress response of a diverse set of species such as , , , , and . In this review, environmental and industrial stressors including desiccation, heat, and cold stress, are cataloged along with their corresponding mechanisms of survival in . Mechanisms of survival are grouped by the type of inducing stress with a focus on adaptations such as synthesis of protective substances, biofilm formation, entering a non-culturable state, enlisting chaperones, transcription and translation regulation, and altering membrane composition. The strategies strains utilize for survival can be leveraged during the development of beneficial strains to increase viability and product efficacy.

摘要

该属的成员具有多种代谢能力,能够适应各种各样的环境。由于其在农业中的生物技术潜力以及在致病性和抗生素抗性方面的医学重要性,该属菌株的应激生理学已得到广泛研究。这种多功能性和科学相关性导致了关于多种物种(如 、 、 、 和 )应激反应的大量信息。在本综述中,包括干燥、热和冷应激在内的环境和工业应激源及其在 中的相应生存机制被编目。生存机制按诱导应激的类型分组,重点关注诸如保护性物质的合成、生物膜形成、进入不可培养状态、招募伴侣蛋白、转录和翻译调控以及改变膜组成等适应方式。在有益菌株的开发过程中,可以利用该属菌株用于生存的策略来提高活力和产品功效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcb5/8141521/859d614359db/fmicb-12-660134-g001.jpg

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