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宫颈癌皮肤转移:一例罕见病例报告。

Skin metastases originated from cervical cancer: A rare case report.

作者信息

Purbadi Sigit, Rustamadji Primariadewi, Purwoto Gatot, Kusuma Fitriyadi, Putra Andi Darma, Scovani Laurensia, Sianturi Ernest Tb

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia.

出版信息

Ann Med Surg (Lond). 2021 May 12;66:102363. doi: 10.1016/j.amsu.2021.102363. eCollection 2021 Jun.

Abstract

INTRODUCTION

Metastases in cervical cancer could be spread through direct local invasion, lymphatic dissemination, or hematogenous dissemination. The most common sites of distant metastases are lungs, bone, and liver. Skin metastases from cervical cancer are categorized as a rare occurrence of metastases. This rarity of the cases has led us to report it.

CASE DESCRIPTION

A 66-year-old multiparous woman diagnosed with stage IIA cervical cancer seven years ago, then she came into our outpatient clinic complained about a brownish white color mass on the left side of the neck that keeps getting bigger over time came from a skin lesion. The lesion was first treated with topical steroid but there was no improvement. Biopsy was done and the result showed a carcinoma metastasis that led to adenosquamous carcinoma or cervical adenocarcinoma. The patient went through chemoradiation with biosensitizer paclitaxel 120 mg/m for six cycles, which began in August 2019 until October 2019. The treatment progress showed a promising result. We observed the patient during treatment until two months after finishing the treatment. At the last visit, the patient came to our outpatient clinic, the mass size decreased significantly, and the skin showed an excellent regeneration sign.

CONCLUSION

The physicians should always consider the patient's history and pay more attention to skin lesions in patients with a history of cervical cancer. The physicians should also perform a thorough physical examination and biopsy to confirm the diagnosis.

摘要

引言

宫颈癌转移可通过直接局部浸润、淋巴道播散或血行播散。远处转移最常见的部位是肺、骨和肝。宫颈癌皮肤转移被归类为罕见的转移情况。病例的这种罕见性促使我们进行报告。

病例描述

一名66岁多产妇女七年前被诊断为IIA期宫颈癌,随后她前来我们的门诊,抱怨颈部左侧有一个棕白色肿块,随着时间推移不断增大,该肿块源于皮肤病变。病变最初用外用类固醇治疗,但没有改善。进行了活检,结果显示为癌转移,导致腺鳞癌或宫颈腺癌。患者从2019年8月至2019年10月接受了六个周期的含生物增敏剂紫杉醇120mg/m²的放化疗。治疗进展显示出有希望的结果。我们在治疗期间观察患者,直至完成治疗后两个月。在最后一次就诊时,患者前来我们的门诊,肿块大小显著减小,皮肤显示出良好的再生迹象。

结论

医生应始终考虑患者的病史,并更加关注有宫颈癌病史患者的皮肤病变。医生还应进行全面的体格检查和活检以确诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e87/8141660/d360e6760026/gr1.jpg

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