Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Kagoshima Kouseiren Hospital, Kagoshima, Japan.
Heart Vessels. 2021 Dec;36(12):1879-1884. doi: 10.1007/s00380-021-01880-5. Epub 2021 May 27.
The incidence of atrial fibrillation (AF) is expected to increase with increasing obesity and number of geriatric patients in Japan. Although higher body mass index and abdominal obesity are associated with an increased risk of AF, the sex-specific relationship between abdominal obesity and new-onset AF is unclear. This study aimed to investigate the sex-specific relationship between abdominal obesity and new-onset AF. This retrospective study evaluated the annual health checkup data of 67,379 adults (33,562 males; age, 54 ± 10 years) without baseline AF from April 2008 to March 2016. Participants were grouped according to waist circumference (WC): large-WC group (males, ≥ 85 cm; females, ≥ 90 cm) and normal-WC group. Logistic regression analyses were performed to determine the strength of the association between abdominal obesity and new-onset AF, overall and separately for males and females. During a median follow-up of 5 years, 280 (0.4%) new cases of AF were recorded. Univariate analysis revealed a significant increase in new-onset AF in males (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.49-2.60; p < 0.001) but not in females (OR, 1.69; 95% CI, 0.96-2.97; p = 0.068) in the large-WC group. After adjusting for clinical variables, multivariate analysis revealed that a large WC was significantly associated with new-onset AF in males (OR, 1.76; 95% CI, 1.31-2.36; p < 0.001) but not in females (OR, 1.22; 95% CI, 0.68-2.18; p = 0.514). Abdominal obesity is associated with an increased risk of new-onset AF in men.
房颤（AF）的发病率预计会随着日本肥胖和老年患者人数的增加而增加。虽然较高的体重指数和腹型肥胖与 AF 风险增加相关，但腹型肥胖与新发 AF 之间的性别特异性关系尚不清楚。本研究旨在探讨腹型肥胖与新发 AF 之间的性别特异性关系。这项回顾性研究评估了 2008 年 4 月至 2016 年 3 月期间 67379 名无基线 AF 的成年人（男性 33562 名，年龄 54 ± 10 岁）的年度健康检查数据。根据腰围（WC）将参与者分为大 WC 组（男性，≥85cm；女性，≥90cm）和正常 WC 组。进行 logistic 回归分析以确定腹型肥胖与新发 AF 之间的关联强度，整体和分别针对男性和女性进行分析。在中位随访 5 年期间，记录了 280 例（0.4%）新发 AF 病例。单因素分析显示，大 WC 组男性新发 AF 的风险显著增加（比值比[OR]，1.97；95%置信区间[CI]，1.49-2.60；p<0.001），但女性无显著增加（OR，1.69；95% CI，0.96-2.97；p=0.068）。在校正临床变量后，多因素分析显示，大 WC 与男性新发 AF 显著相关（OR，1.76；95% CI，1.31-2.36；p<0.001），但与女性无关（OR，1.22；95% CI，0.68-2.18；p=0.514）。腹型肥胖与男性新发 AF 风险增加相关。
