Department of Pharmacy, Akita University Hospital, Akita, Japan.
Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan.
J Clin Pharm Ther. 2021 Dec;46(6):1800-1803. doi: 10.1111/jcpt.13451. Epub 2021 May 27.
We aim to add to the few reports on tacrolimus concentrations in breast milk and in maternal, umbilical vein and neonatal blood after maternal renal transplantation.
In a 30-year-old pregnant woman, the tacrolimus concentration at delivery was the same in maternal, umbilical vein and neonatal blood. The breast milk/maternal blood tacrolimus ratio ranged from 0.40 to 0.64.
The maternal and neonatal blood tacrolimus concentrations at birth are equivalent; thus, one must assume that maternal tacrolimus concentrations directly affect the foetus and/or neonate. Tacrolimus is not detectable in the neonate 3 weeks after birth, suggesting that there is minimal transfer through breast milk.
我们旨在增加少数关于肾移植母亲的母乳以及母亲、脐静脉和新生儿血液中他克莫司浓度的报告。
在一名 30 岁的孕妇中，分娩时的他克莫司浓度在母亲、脐静脉和新生儿血液中相同。母乳/母亲血液他克莫司比值范围为 0.40 至 0.64。
出生时母亲和新生儿血液中的他克莫司浓度相当；因此，必须假设母亲的他克莫司浓度直接影响胎儿和/或新生儿。新生儿在出生后 3 周内检测不到他克莫司，表明通过母乳的转移量很少。
