is a full time assistant professor at Texas Wesleyan University Graduate Programs of Nurse Anesthesia. Email:
is the assistant program director at Texas Wesleyan University Graduate Programs of Nurse Anesthesia.
AANA J. 2021 Jun;89(3):245-253.
Surgical site infection (SSI) is a common preventable iatrogenic infection following surgery with an approximated overall occurrence of 2-4%. Despite numerous studies, controversies still exist regarding the efficacy, safety, and cost effectiveness of strategies to decrease SSI. The World Health Organization issued recommendations for the prevention of SSIs including oxygenation with 80% fraction of inspired oxygen (FiO). The primary outcome of our systematic review and metaanalysis was the effect of high inspired FiO related to SSI in the colorectal surgery population. Secondary outcomes included incidence of anastomotic leaks and length of hospital stay. Eleven trials consisting of 8245 were included in the analysis. We found moderate quality of evidence that 80% FiO2 was not effective in reducing SSI (RR, 0.91; 95% CI, 0.74 to 1.13; P = .41) anastomotic leaks (RR, 0.75; 95% CI, 0.53 to 1.06; P = 0.10). Conversely, we found low quality evidence of no effect on length of stay measured in days (MD, 0.39; 95% CI -0.59 to 1.36; P = 0.44). Although additional studies are required to decrease heterogeneity of the studies, the current review showed high FiO does not decrease the incidence of SSI in the colorectal surgery population.
手术部位感染（SSI）是手术后常见的可预防的医源性感染，其总发生率约为 2-4%。尽管进行了大量研究，但关于降低 SSI 的策略的疗效、安全性和成本效益仍存在争议。世界卫生组织发布了预防 SSI 的建议，包括用 80%吸氧分数（FiO）进行氧合。我们的系统评价和荟萃分析的主要结果是高吸入 FiO 与结直肠手术人群 SSI 相关的效果。次要结果包括吻合口漏和住院时间的发生率。有 11 项试验（包括 8245 名患者）纳入了分析。我们发现中等质量的证据表明，80%的 FiO2 不能有效降低 SSI（RR，0.91；95%CI，0.74 至 1.13；P = 0.41）和吻合口漏（RR，0.75；95%CI，0.53 至 1.06；P = 0.10）。相反，我们发现低质量证据表明，在住院天数（MD，0.39；95%CI -0.59 至 1.36；P = 0.44）方面没有效果。尽管需要进一步的研究来降低研究的异质性，但目前的综述表明，高 FiO 并不能降低结直肠手术人群 SSI 的发生率。
