Department of Neurology, Institute of Translational Neurology, University Hospital Muenster, Muenster, Germany.
Department of Neurology, University Hospital Duesseldorf, Duesseldorf, Germany.
Cell Physiol Biochem. 2021 May 28;55(S3):145-156. doi: 10.33594/000000375.
The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage identity, regulation, and effector function. Identified ion channels include Ca release-activated Ca, transient receptor potential, P2X, volume-regulated anion and K channels Kv1.3 and KCa3.1. Ion channel modulation represents a promising therapeutic approach for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. This review summarizes studies with gene-targeted mice and pharmacological modulators affecting Treg number and function. Furthermore, participation of ion channels is illustrated and the power of future research possibilities is discussed.
调节性 T 细胞（Tregs）的群体对于免疫自身耐受和稳态至关重要。适当的离子调节有助于 Treg 谱系的身份、调节和效应功能。已鉴定的离子通道包括 Ca 释放激活的 Ca2+、瞬时受体电位、P2X、体积调节阴离子和 Kv1.3 和 KCa3.1 钾通道。离子通道调节代表了治疗类风湿关节炎和多发性硬化症等自身免疫性疾病的有前途的治疗方法。本综述总结了靶向基因敲除小鼠和影响 Treg 数量和功能的药理学调节剂的研究。此外，还说明了离子通道的参与，并讨论了未来研究可能性的力量。
