Micheletti L, Borgno G, Barbero M, Preti M, Cavanna L, Benedetto C, Ghiringhello B
Institute of Gynecology and Obstetrics, University of Turin, Italy.
J Reprod Med. 1988 Jun;33(6):539-41.
We studied the frequency and distribution of cellular atypia in 448 cases of vulvar dystrophy. The total frequency was 9.4%. Atypia was found almost exclusively in hyperplastic areas. Epithelial changes suggestive of human papillomavirus infection were found in 14.2% of the atypical dystrophies. During the follow-up of 78 patients with typical dystrophy, mild atypia developed in three cases, but with the continuation of medical treatment it disappeared in two cases. Eleven cases of atypical dystrophy were followed for 3-48 months; three patients with severe atypia underwent surgical treatment, and eight with mild atypia underwent medical treatment. Among the last patients, six showed regression and two, progression of the atypia.
我们研究了448例外阴营养不良患者细胞异型性的频率和分布情况。总频率为9.4%。异型性几乎仅见于增生区域。在14.2%的非典型性营养不良患者中发现了提示人乳头瘤病毒感染的上皮变化。在对78例典型营养不良患者的随访过程中，有3例出现了轻度异型性，但随着治疗的继续，其中2例的异型性消失。对11例非典型性营养不良患者进行了3至48个月的随访；3例重度异型性患者接受了手术治疗，8例轻度异型性患者接受了药物治疗。在最后一组患者中，6例异型性消退，2例异型性进展。
