Bergman A, Karram M, Bhatia N N
Department of Obstetrics and Gynecology, Harbor-University of California, Los Angeles School of Medicine.
J Reprod Med. 1988 Jun;33(6):542-4.
Fifteen women complaining of vulvar pruritus of at least three months' duration were evaluated clinically and noted to have white lesions of the vulva consistent with hyperplastic dystrophy. Histologic evaluation confirmed the diagnosis, and all the patients were treated with local application of halocidine cream and crotamiton cream. After six weeks of therapy a repeat clinical and histologic evaluation revealed 13 of the 15 patients to be completely relieved of the vulvar pruritus, and 12 of the 13 were histologically demonstrated to have complete reversal of the hyperplastic process to normal skin. The other two denied any improvement in their pruritus and were histologically noted to have persistence of the hyperplastic process. A good clinical and histologic correlation was noted following local steroid application in patients with histologically proven hyperplastic dystrophy.
对15名主诉外阴瘙痒至少持续3个月的女性进行了临床评估，发现她们有与增生性营养不良相符的外阴白色病变。组织学评估证实了诊断，所有患者均接受了局部应用卤米松乳膏和克罗米通乳膏的治疗。治疗6周后，重复进行临床和组织学评估，发现15名患者中有13名的外阴瘙痒完全缓解，13名患者中有12名在组织学上显示增生过程完全逆转至正常皮肤。另外两名患者否认瘙痒有任何改善，组织学检查发现增生过程持续存在。在组织学证实为增生性营养不良的患者中，局部应用类固醇后发现临床与组织学有良好的相关性。
