Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Exp Mol Med. 2021 May;53(5):823-834. doi: 10.1038/s12276-021-00630-x. Epub 2021 May 28.
Over the years, interleukin (IL)-27 has received much attention because of its highly divergent, sometimes even opposing, functions in immunity. IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions. Furthermore, there is emerging evidence that IL-30 itself may perform immunomodulatory functions independent of Ebi3 or other binding partners and that IL-30 production is strongly associated with certain cancers in humans. In this review, we will discuss the biology of IL-30 and other IL-30-associated cytokines and their functions in inflammation and cancer.
多年来，白细胞介素 (IL)-27 因其在免疫中的高度差异，甚至相反的功能而受到广泛关注。IL-30 是与 Ebi3 一起形成 IL-27 的 p28 亚基，也被称为 IL-27p28 或 IL-27A，一直被认为是代表 IL-27 的替代物。然而，后来发现 IL-30 可以与其他蛋白亚基形成复合物，可能导致重叠或离散的功能。此外，有新的证据表明，IL-30 本身可能具有独立于 Ebi3 或其他结合伙伴的免疫调节功能，并且 IL-30 的产生与人的某些癌症密切相关。在这篇综述中，我们将讨论 IL-30 和其他与 IL-30 相关的细胞因子的生物学特性及其在炎症和癌症中的功能。
