Castelo Raísa, Attik Nina, Catirse Alma Blasida Concepcion Elizaur Benitez, Pradelle-Plasse Nelly, Tirapelli Camila, Grosgogeat Brigitte
Departmento de Materiais Dentários e Prótese, Faculdade de Odontologia de Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Université de Lyon - Université Claude Bernard Lyon 1, UMR CNRS 5615, Laboratoire des Multimatériaux et Interfaces, F-69622, France.
Université de Lyon - Université Claude Bernard Lyon 1, UMR CNRS 5615, Laboratoire des Multimatériaux et Interfaces, F-69622 Villeurbanne, France; Université de Lyon - Université Claude Bernard Lyon 1, Faculté d'Odontologie, 69008 Lyon, France.
Br Dent J. 2021 May 27. doi: 10.1038/s41415-021-3003-2.
Aim This systematic review aimed to critically summarise the results of clinical studies investigating agents able to: stop the progression of carious lesions; stop the development of new root carious lesions; preserve the vitality of the infected dental tissues; and increase the surface hardness or change of surface texture, in middle-age and older adults.Methods PubMed, Scopus, and Web of Science were searched systematically, following PRISMA guidelines. Clinical trials published from 2011 to 2020 (March) were included. This systematic review is registered in the PROSPERO database (CRD42018104399). Languages were restricted to English.Results Thirteen of 312 studies were eligible for this review. Eight agents were identified in the studies and their efficacy was assessed using different methods. The agents that presented valuable results on preventing or arresting root caries were 38% silver diamine fluoride (SDF), arginine-containing toothpaste and high-fluoride toothpastes.Conclusions Based on the selected studies' findings, annual applications of 38% SDF could be the most effective treatment for root caries in older adults. In addition, the daily use of a 1.5% arginine toothpaste or a high-fluoride toothpaste could also be recommended. More research on root caries-specific diagnostic methods, especially at very early stages, is necessary.
目的 本系统评价旨在批判性地总结临床研究结果,这些研究调查了能够在中年及老年人群中:阻止龋损进展;阻止新的根龋病变发展;保持感染牙体组织活力;以及增加表面硬度或改变表面质地的药物。
方法 按照PRISMA指南,系统检索了PubMed、Scopus和Web of Science。纳入2011年至2020年3月发表的临床试验。本系统评价已在PROSPERO数据库(CRD42018104399)中注册。语言限于英语。
结果 312项研究中有13项符合本评价标准。研究中确定了8种药物,并使用不同方法评估了它们的疗效。在预防或阻止根龋方面呈现出有价值结果的药物是38%氟化亚锡(SDF)、含精氨酸牙膏和高氟牙膏。
结论 根据所选研究结果,每年应用38% SDF可能是治疗老年人根龋最有效的方法。此外,也可推荐每日使用1.5%精氨酸牙膏或高氟牙膏。有必要对根龋特异性诊断方法进行更多研究,尤其是在非常早期阶段。