牙源性间充质干细胞的关键标志物和表观遗传修饰
Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells.
作者信息
Chen Jingqiu, Zheng Xiaodan, Rao Nanquan, Huang Yao, Liu Juan, Li Yanhong, Zhang Jun
机构信息
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
出版信息
Stem Cells Int. 2021 May 8;2021:5521715. doi: 10.1155/2021/5521715. eCollection 2021.
Abstract
As a novel research hotspot in tissue regeneration, dental-derived mesenchymal stromal cells (MSCs) are famous for their accessibility, multipotent differentiation ability, and high proliferation. However, cellular heterogeneity is a major obstacle to the clinical application of dental-derived MSCs. Here, we reviewed the heterogeneity of dental-derived MSCs firstly and then discussed the key markers and epigenetic modifications related to the proliferation, differentiation, immunomodulation, and aging of dental-derived MSCs. These messages help to control the composition and function of dental-derived MSCs and thus accelerate the translation of cell therapy into clinical practice.
摘要
作为组织再生领域的一个新型研究热点，牙源性间充质基质细胞（MSCs）因其易于获取、多能分化能力和高增殖性而闻名。然而，细胞异质性是牙源性MSCs临床应用的主要障碍。在此，我们首先综述了牙源性MSCs的异质性，然后讨论了与牙源性MSCs增殖、分化、免疫调节和衰老相关的关键标志物和表观遗传修饰。这些信息有助于控制牙源性MSCs的组成和功能，从而加速细胞治疗向临床实践的转化。
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