既往甲状腺切除患者的乳腺癌：哪些甲状腺疾病是危险因素？
Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?
作者信息
Graceffa Giuseppa, Scerrino Gregorio, Militello Gabriella, Laise Iole, Randisi Brenda, Melfa Giuseppina, Orlando Giuseppina, Mazzola Sergio, Cipolla Calogero, Cocorullo Gianfranco
机构信息
Department of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Department of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
出版信息
Future Sci OA. 2021 Mar 29;7(5):FSO699. doi: 10.2144/fsoa-2021-0029.
The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.
本研究的目的是评估是否存在某些甲状腺疾病会使乳腺癌在之后出现，以及自身免疫的作用。这是一项回顾性观察研究。将总共410名女性（甲状腺手术且之后患乳腺癌）和524名女性（仅接受甲状腺手术）在甲状腺病理结果、甲状腺激素、甲状腺自身免疫及乳腺癌类型方面进行了比较。甲状腺自身免疫，尤其是抗甲状腺过氧化物酶抗体，显著增加了患乳腺癌的风险（p < 0.01）；然而，对于其他甲状腺疾病，包括甲状腺癌，情况并非如此。没有哪种乳腺癌变体占主导，且只有甲状腺自身免疫与乳腺癌风险相关。需要进一步研究来解释不同抗甲状腺抗体的影响。
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