Tamura G, Masuda T, Satodate R, Ishida M, Saitoh K
Dept. of Pathology II, School of Med., Iwate Med. Univ.
Gan No Rinsho. 1988 Jul;34(8):977-80.
The nuclear area (NA) and nuclear form factor (NFF) (NFF = 4.pi.NA/P2. Na, nuclear area; P, perimeter) have been measured in fifteen stage III patients with an invasive ductal breast cancer, using an image analyzer (IBAS-2000, Zeiss). The NA has been revealed as being 41.8 +/- 8.82 micrograms2 (mean +/- S.D.) in five-year survivors (n = 8), and 59.4 +/- 12.9 micrograms2 in non-survivors (n = 7). The NFF was found to be 0.74 +/- 0.038 in those who survived, and 0.69 +/- 0.028 in non-survivors. The NA was significantly lager (p less than 0.01) and the NFF significantly lower (p less than 0.05) in the non-survivors than in the survivors. NA and NFF are considered to be helpful in determining the prognosis of breast cancer patients in stage III.
使用图像分析仪（IBAS - 2000，蔡司）对15例III期浸润性导管乳腺癌患者的核面积（NA）和核形态因子（NFF）（NFF = 4π×NA / P²。Na，核面积；P，周长）进行了测量。结果显示，5年生存者（n = 8）的NA为41.8±8.82平方微米（平均值±标准差），非生存者（n = 7）的NA为59.4±12.9平方微米。生存者的NFF为0.74±0.038，非生存者的NFF为0.69±0.028。非生存者的NA显著更大（p＜0.01），NFF显著更低（p＜0.05）。NA和NFF被认为有助于确定III期乳腺癌患者的预后。
