Xia Hui, Wang Chao-Chao, Wang Rong-Ye, Liang Nai-Yun, Wang Xin-Yu, Song Yue-Lin, Zhao Yun-Fang, Huo Hui-Xia, Li Jun
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2021 May;46(9):2215-2219. doi: 10.19540/j.cnki.cjcmm.20210115.602.
This study aims to study the chemical components from the gum resin of Boswellia carterii. Five cembranoid diterpenes were isolated from the gum resin of B. carterii by various of column chromatographies including silica gel, Sephadex LH-20, and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties, mass spectrometry(MS), nuclear magnetic resonance(NMR), Ultraviolet(UV) and infrared(IR) spectroscopic data. These compounds were identified as(1S,2E,4R,5S,7E,11E)-4-methoxy-5-hydroxycembrane(1),(1R*,4R*,5E,8E,12E,15E)-4-hydroxycembra-5,8,12,15-tetraene(2), cembrene A(3),(3S,4S,7R)-4-hydroxycembrane(4), and pavidolide D(5). Compound 1 was a new compound. Compounds 2, 4, and 5 were obtained from the gum resin of B. carterii for the first time. Compound 2 showed weak inhibition on the human liver cancer cell line HepG2.
本研究旨在研究乳香树(Boswellia carterii)树脂的化学成分。通过硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱和半制备高效液相色谱等多种柱色谱方法,从乳香树树脂中分离出5种松香烷型二萜。根据其物理化学性质、质谱(MS)、核磁共振(NMR)、紫外(UV)和红外(IR)光谱数据确定了它们的结构。这些化合物被鉴定为(1S,2E,4R,5S,7E,11E)-4-甲氧基-5-羟基松香烷(1)、(1R*,4R*,5E,8E,12E,15E)-4-羟基松香-5,8,12,15-四烯(2)、松香烯A(3)、(3S,4S,7R)-4-羟基松香烷(4)和帕维多利德D(5)。化合物1是一种新化合物。化合物2、4和5首次从乳香树树脂中获得。化合物2对人肝癌细胞系HepG2显示出微弱的抑制作用。