Suppr超能文献

[一种来自乳香树胶树脂的新西松烷型二萜]

[One new cembranoid diterpene from gum resin of Boswellia carterii].

作者信息

Xia Hui, Wang Chao-Chao, Wang Rong-Ye, Liang Nai-Yun, Wang Xin-Yu, Song Yue-Lin, Zhao Yun-Fang, Huo Hui-Xia, Li Jun

机构信息

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2021 May;46(9):2215-2219. doi: 10.19540/j.cnki.cjcmm.20210115.602.

Abstract

This study aims to study the chemical components from the gum resin of Boswellia carterii. Five cembranoid diterpenes were isolated from the gum resin of B. carterii by various of column chromatographies including silica gel, Sephadex LH-20, and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties, mass spectrometry(MS), nuclear magnetic resonance(NMR), Ultraviolet(UV) and infrared(IR) spectroscopic data. These compounds were identified as(1S,2E,4R,5S,7E,11E)-4-methoxy-5-hydroxycembrane(1),(1R*,4R*,5E,8E,12E,15E)-4-hydroxycembra-5,8,12,15-tetraene(2), cembrene A(3),(3S,4S,7R)-4-hydroxycembrane(4), and pavidolide D(5). Compound 1 was a new compound. Compounds 2, 4, and 5 were obtained from the gum resin of B. carterii for the first time. Compound 2 showed weak inhibition on the human liver cancer cell line HepG2.

摘要

本研究旨在研究乳香树(Boswellia carterii)树脂的化学成分。通过硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱和半制备高效液相色谱等多种柱色谱方法,从乳香树树脂中分离出5种松香烷型二萜。根据其物理化学性质、质谱(MS)、核磁共振(NMR)、紫外(UV)和红外(IR)光谱数据确定了它们的结构。这些化合物被鉴定为(1S,2E,4R,5S,7E,11E)-4-甲氧基-5-羟基松香烷(1)、(1R*,4R*,5E,8E,12E,15E)-4-羟基松香-5,8,12,15-四烯(2)、松香烯A(3)、(3S,4S,7R)-4-羟基松香烷(4)和帕维多利德D(5)。化合物1是一种新化合物。化合物2、4和5首次从乳香树树脂中获得。化合物2对人肝癌细胞系HepG2显示出微弱的抑制作用。

相似文献

1
[One new cembranoid diterpene from gum resin of Boswellia carterii].
Zhongguo Zhong Yao Za Zhi. 2021 May;46(9):2215-2219. doi: 10.19540/j.cnki.cjcmm.20210115.602.
2
[Chemical constituents of diterpenoids from Boswellia carterii].
Zhongguo Zhong Yao Za Zhi. 2023 May;48(9):2464-2470. doi: 10.19540/j.cnki.cjcmm.20230202.201.
3
Hepatoprotective prenylaromadendrane-type diterpenes from the gum resin of Boswellia carterii.
J Nat Prod. 2013 Nov 22;76(11):2074-9. doi: 10.1021/np400526b. Epub 2013 Nov 6.
4
Bioactive cembrane-type diterpenoids from the gum-resin of Boswellia carterii.
Fitoterapia. 2019 Sep;137:104263. doi: 10.1016/j.fitote.2019.104263. Epub 2019 Jul 8.
5
Five terpenoids from the gum resin of Boswellia carterii and their cytotoxicity.
Fitoterapia. 2021 Oct;154:105017. doi: 10.1016/j.fitote.2021.105017. Epub 2021 Aug 18.
6
Anti-inflammatory and hepatoprotective cembranoid alcohols from the Gum Resin of Boswellia carterii.
Fitoterapia. 2021 Nov;155:105064. doi: 10.1016/j.fitote.2021.105064. Epub 2021 Oct 14.
7
Bioactive cembrane diterpenoids from the gum resin of Boswellia carterii.
Fitoterapia. 2020 Oct;146:104699. doi: 10.1016/j.fitote.2020.104699. Epub 2020 Aug 4.
9
New terpenoids, olibanumols D-G, from traditional Egyptian medicine olibanum, the gum-resin of Boswellia carterii.
J Nat Med. 2011 Jan;65(1):129-34. doi: 10.1007/s11418-010-0472-z. Epub 2010 Oct 16.
10
Hepatoprotective triterpenes from the gum resin of Boswellia carterii.
Fitoterapia. 2016 Mar;109:266-73. doi: 10.1016/j.fitote.2015.12.018. Epub 2015 Dec 29.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验