Department of Pharmacy, Xuanwu Hospital，The First Clinical Medical College of Capital Medical University, Beijing 100053, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Fitoterapia. 2019 Sep;137:104263. doi: 10.1016/j.fitote.2019.104263. Epub 2019 Jul 8.
Chemical examination of the gum-resin of Boswellia carterii resulted in the isolation and characterization of eighteen new cembrane-type diterpenoids, named as Boscartins P-AG (1-18) and eight known ones. Their structures were established on the basis of extensive spectroscopic (2D NMR, IR, CD, MS and X-ray) analysis in combination with modified Mosher's method. All compounds featured unusual 1,12-oxygenated tetrahydrofuran functionalities, and were evaluated for hepatoprotective activity against D-galactosamine-induced HL-7702 cell damage and cytotoxic activity against MCF-7 human breast cancer cell in vitro. Compounds 1, 6-10, 12-13, 16-17 and 21-25 (10 μM) showed some hepatoprotective activity against D-galactosamine-induced HL-7702 cell damage.
对乳香的胶树脂进行化学研究，分离并鉴定了 18 种新型的倍半萜二萜，命名为 Boscartins P-AG（1-18）和 8 种已知化合物。基于广泛的光谱（二维 NMR、IR、CD、MS 和 X 射线）分析，并结合改进的 Mosher 方法，确定了它们的结构。所有化合物均具有不常见的 1,12-氧代四氢呋喃官能团，并对其进行了保肝活性评估，以检测其对 D-半乳糖胺诱导的 HL-7702 细胞损伤的抑制作用，以及对 MCF-7 人乳腺癌细胞的体外细胞毒性作用。化合物 1、6-10、12-13、16-17 和 21-25（10μM）对 D-半乳糖胺诱导的 HL-7702 细胞损伤具有一定的保肝活性。
