影响范围：胎盘疟疾分子机制的结构见解。
mSphere of Influence: Structural Insights into the Molecular Mechanism Underlying Placental Malaria.
机构信息
Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
出版信息
mSphere. 2021 Jun 30;6(3):e0039121. doi: 10.1128/mSphere.00391-21. Epub 2021 May 28.
Maria del Pilar Quintana works on immunology and pathogenesis of severe malaria. In this mSphere of Influence article, she reflects on how the papers "Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA" (R. Ma, T. Lian, R. Huang, J. P. Renn, J. D. Petersen, J. Zimmerberg, P. E. Duffy, N. H. Tolia, Nat Microbiol 6:380-391, 2021, https://doi.org/10.1038/s41564-020-00858-9) and "Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding" (K. Wang, R. Dagil, T. Lavsten, S. K. Misra, C. B. Spliid, Y. Wang, T. Gustavsson, D. R. Sandoval, E. E. Vidal-Calvo, S. Choudary, M. O. Agerback, K. Lindorff-Larsen, M. A. Nielsen, T. G. Theander, J. S. Sharp, T. M. Clausen, P. Gourdon, A. Salanti, A. Salanti, Nat Commun 12:2956, 2021, https://doi.org/10.1038/s41467-021-23254-1) shed light on the precise structural details behind Plasmodium falciparum VAR2CSA binding to chondroitin sulfate A (CSA) in the placenta and how these novel insights have changed the way she will approach her work toward the discovery of new broadly cross-reactive/inhibitory antibodies targeting VAR2CSA.
玛丽亚·德尔·皮拉尔·金塔纳从事免疫学和严重疟疾发病机制的研究。在这篇《mSphere》影响力文章中，她反思了两篇论文“结构基础揭示恶性疟原虫 VAR2CSA 通过胎盘的机制”（R. Ma, T. Lian, R. Huang, J. P. Renn, J. D. Petersen, J. Zimmerberg, P. E. Duffy, N. H. Tolia, Nat Microbiol 6:380-391, 2021, https://doi.org/10.1038/s41564-020-00858-9）和“冷冻电镜揭示胎盘疟疾 VAR2CSA 的结构，并提供硫酸软骨素结合的分子见解”（K. Wang, R. Dagil, T. Lavsten, S. K. Misra, C. B. Spliid, Y. Wang, T. Gustavsson, D. R. Sandoval, E. E. Vidal-Calvo, S. Choudary, M. O. Agerback, K. Lindorff-Larsen, M. A. Nielsen, T. G. Theander, J. S. Sharp, T. M. Clausen, P. Gourdon, A. Salanti, A. Salanti, Nat Commun 12:2956, 2021, https://doi.org/10.1038/s41467-021-23254-1）如何阐明恶性疟原虫 VAR2CSA 与胎盘内硫酸软骨素 A（CSA）结合的精确结构细节，以及这些新的见解如何改变她研究新的广泛交叉反应/抑制性抗体靶向 VAR2CSA 的方法。
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