在喂食含胆固醇和胆酸饮食的小鼠中，β-鼠胆酸对肝脏HMG-CoA还原酶活性的抑制作用。
Suppression of hepatic HMG-CoA reductase activity by beta-muricholic acid in mice fed a diet containing cholesterol and cholic acid.
作者信息
Fujino Y, Nakayama K, Yoshimura K, Furuya Y, Yonaga T
机构信息
Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan.
出版信息
Jpn J Pharmacol. 1988 Apr;46(4):421-3. doi: 10.1254/jjp.46.421.
A diet containing cholesterol and cholic acid (SID) is known to induce the formation of cholesterol fatty liver as well as cholesterol gallstones. The activity of HMG-CoA reductase, one of the key enzymes for cholesterol synthesis in the liver, is significantly lowered by addition of beta-muricholic acid to SID. The prevention of fatty liver formation by beta-muricholic acid was accompanied by the suppression of HMG-CoA reductase activity.
已知含有胆固醇和胆酸（SID）的饮食会诱发胆固醇性脂肪肝以及胆固醇胆结石的形成。肝脏中胆固醇合成的关键酶之一HMG-CoA还原酶的活性，在向SID中添加β-鼠胆酸后会显著降低。β-鼠胆酸对脂肪肝形成的预防作用伴随着HMG-CoA还原酶活性的抑制。
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