Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Photodiagnosis Photodyn Ther. 2021 Sep;35:102356. doi: 10.1016/j.pdpdt.2021.102356. Epub 2021 May 25.
Different therapies such as clindamycin, rifampicin, isotretinoin, or corticosteroids have been used for folliculitis decalvans with poor results. Recently, PDT has been used for treating folliculitis decalvans more frequently. However, the efficacy of PDT for treating folliculitis decalvans is lacking consensus. In this study, we conducted a retrospective analysis to evaluated the status of PDT for the treatment of folliculitis decalvans.
13 cases of folliculitis decalvans patients were treated with ALA-PDT. The treatment totals 3 times, and the interval between each treatment was 10-14 days. A follow-up was conducted at 12 months after the last treatment. The condition was graded according to the following evaluation criteria: recovery, significant improvement, moderate improvement, ineffective.
A total of 7 cases improved significantly, and 6 cases improved moderately followed the first treatment. After the second treatment, 10 cases showed significant improvement, and 2 cases responded poorer than the first treatment. After the third treatment, 4 cases recovered, 7 cases improved significantly, and 2 case moderately improved. At the 12-months follow-up, 9 out of 13 patients were well controlled and with no recurrence. The other 4 patients relapsed.
In summary, photodynamic therapy shows overall favorable effect on folliculitis decalvans and should be considered as a method for the treatment of folliculitis decalvans.
不同的疗法，如克林霉素、利福平、异维 A 酸或皮质类固醇，已被用于治疗脱发性毛囊炎，但效果不佳。最近，PDT 已被更频繁地用于治疗脱发性毛囊炎。然而，PDT 治疗脱发性毛囊炎的疗效尚未达成共识。在本研究中，我们进行了一项回顾性分析，以评估 PDT 治疗脱发性毛囊炎的现状。
13 例脱发性毛囊炎患者接受 ALA-PDT 治疗。治疗总次数为 3 次，每次治疗间隔 10-14 天。末次治疗后 12 个月进行随访。根据以下评估标准对病情进行分级：痊愈、显著改善、中度改善、无效。
首次治疗后，7 例明显改善，6 例中度改善。第二次治疗后，10 例明显改善，2 例较第一次治疗效果差。第三次治疗后，4 例痊愈，7 例明显改善，2 例中度改善。12 个月随访时，13 例患者中 9 例控制良好，无复发，4 例复发。
综上所述，光动力疗法对脱发性毛囊炎总体疗效良好，可作为脱发性毛囊炎的治疗方法。
