Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, United States.
Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, United States; Department of Pathology, Children Hospital of Orange County (CHOC), Orange, CA, United States.
Pathol Res Pract. 2021 Jul;223:153462. doi: 10.1016/j.prp.2021.153462. Epub 2021 May 13.
Solid pseudopapillary neoplasm (SPN) and well differentiated pancreatic neuroendocrine tumor (PNET) can show significant cytomorphological overlap. In this study, we evaluated the role of INSM1 and LEF1 immunohistochemical stains in distinguishing between these two tumors. 22 SPN and 25 PNET surgically resected cases were stained for both INSM1 and LEF1. All the 22 cases of SPN showed strong and diffuse nuclear staining for LEF1 (in >95 % of tumor cells), while all 25 PNET were negative for LEF1. All 25 PNET cases were positive for INSM1 (moderate to strong intensity nuclear staining in >50 % of the tumor cells), while all 22 cases of SPN were negative for INSM1. The results of our study show that a limited panel comprising of INSM1 and LEF1 immunostains accurately distinguishes between SPN and PNET.
实性假乳头状肿瘤（SPN）和高分化胰腺神经内分泌肿瘤（PNET）在细胞学形态上有很大的重叠。在这项研究中，我们评估了 INSM1 和 LEF1 免疫组化染色在鉴别这两种肿瘤中的作用。22 例 SPN 和 25 例 PNET 手术切除标本均进行了 INSM1 和 LEF1 的染色。22 例 SPN 均显示 LEF1 的强而弥漫的核染色（>95%的肿瘤细胞），而 25 例 PNET 均为 LEF1 阴性。25 例 PNET 均为 INSM1 阳性（>50%的肿瘤细胞中具有中度至强的核染色强度），而 22 例 SPN 均为 INSM1 阴性。我们的研究结果表明，一个包含 INSM1 和 LEF1 免疫组化染色的有限组合可以准确地区分 SPN 和 PNET。
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