Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
Res Vet Sci. 2021 Jul;137:243-251. doi: 10.1016/j.rvsc.2021.05.010. Epub 2021 May 21.
The development and early morphological features of feline hip osteoarthritis (OA) are largely unknown. Tears in the acetabular labrum and at the chondrolabral transition zone are suggested to be important in the pathogenesis of human hip OA, but in cats such lesions have not been described. We investigated associations between computed tomography (CT)-detected joint changes and microscopic articular cartilage lesions, the distribution of detected changes, and histologically evaluated the acetabular margin (AM) in hip joints from 20 cats. Histologic evaluation was undertaken on at least one joint from each cat. CT-detected joint changes and articular cartilage lesions were graded and the histological appearance of CT-detected osteophytes evaluated. The majority of CT-detected lesions and cartilage lesions were mild. Whole-joint CT scores and AM osteophyte CT scores showed moderate to strong correlation with cartilage scores. The odds were higher for presence of CT-detected osteophytes in craniodorsal, cranial, cranioventral, ventral and dorsal AM regions. Peripheral acetabular regions showed higher cartilage lesion grades than central regions. Tears, seen as fissures/clefts, in labral and perilabral tissues were common. CT-detected AM osteophytes morphologically presented as pointed sclerotic bone, spur-shaped bone or rounded chondro-osteophytes. The results suggest that CT is a valuable tool for diagnosing early feline hip OA. CT-detected osteophytes showed variable histologic morphologies, which may implicate different disease mechanisms and/or disease stages. Tears in the AM could represent an early event in feline hip OA and this warrants further investigation.
猫髋关节骨关节炎（OA）的发展和早期形态特征在很大程度上尚不清楚。有人认为，髋臼唇撕裂和软骨唇交界处的撕裂在人类髋关节 OA 的发病机制中很重要，但在猫中尚未描述过此类病变。我们研究了 CT 检测到的关节变化与微观关节软骨病变之间的关联、检测到的变化的分布，并对 20 只猫的髋关节进行了组织学评估髋臼缘（AM）。对每只猫的至少一个关节进行了组织学评估。对 CT 检测到的关节变化和软骨病变进行分级，并评估 CT 检测到的骨赘的组织学表现。大多数 CT 检测到的病变和软骨病变为轻度。全关节 CT 评分和 AM 骨赘 CT 评分与软骨评分呈中度至强相关性。在颅背、颅顶、颅腹、腹侧和背侧 AM 区域，CT 检测到的骨赘存在的可能性更高。髋臼的外周区域比中央区域有更高的软骨病变分级。常见到唇状和唇旁组织中有撕裂，表现为裂隙/裂缝。CT 检测到的 AM 骨赘形态上表现为尖锐的硬化骨、骨刺状骨或圆形软骨骨赘。结果表明，CT 是诊断早期猫髋关节 OA 的一种有价值的工具。CT 检测到的骨赘具有不同的组织学形态，这可能暗示了不同的疾病机制和/或疾病阶段。AM 中的撕裂可能代表猫髋关节 OA 的早期事件，这需要进一步研究。
