ENROLL-HD 数据：青少年和儿童亨廷顿病的患病率是否被高估了？
Data from ENROLL-HD: Is the prevalence of juvenile and pediatric Huntington's disease overestimated?
机构信息
Department of Neurology, Huntington Center North Rhine-Westphalia, St. Josef-Hospital Bochum, Gudrunstraße 56, 44791, Bochum, Germany.
Department of Neurology, Huntington Center North Rhine-Westphalia, St. Josef-Hospital Bochum, Gudrunstraße 56, 44791, Bochum, Germany.
出版信息
Parkinsonism Relat Disord. 2021 Jul;88:1-2. doi: 10.1016/j.parkreldis.2021.05.012. Epub 2021 May 20.
BACKGROUND
No study investigated the prevalence of pediatric Huntington's Disease.
METHODS
Prevalence was analyzed in ENROLL-HD from participants and family trees.
RESULTS
50 compared with 7544 adult (0.66%) and 22 out of 16,124 family participants (0.14%) were pediatric.
CONCLUSIONS
The pediatric prevalence in the biggest HD study ranges unexpected low between 0.14 and 0.66%.
背景
目前尚无研究调查儿科亨廷顿病的患病率。
方法
本研究通过对 ENROLL-HD 参与者及其家系进行分析，对患病率进行了研究。
结果
50 名儿科患者与 7544 名成年患者（0.66%）和 16124 名家系参与者中的 22 名（0.14%）相比较。
结论
在最大的亨廷顿病研究中，儿科患病率在 0.14%至 0.66%之间，这一范围出人意料地低。
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