Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA.
School of Public Health, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Vet Clin North Am Food Anim Pract. 2021 Jul;37(2):253-266. doi: 10.1016/j.cvfa.2021.03.002.
Studies have sought to develop effective vaccines against infectious bovine keratoconjunctivitis (IBK). Most research has focused on parenterally administered vaccines against Moraxella bovis antigens; however, researchers have also included Moraxella bovoculi antigens in vaccines to prevent IBK. Critical knowledge gaps remain as to which Moraxella spp antigens might be completely protective, and whether systemic, mucosal, or both types of immune responses are required for protection against IBK associated with Moraxella spp. Immune responses to commensal Moraxella spp residing in the upper respiratory tract and eye have not been analyzed to determine if these responses control colonization or contribute to IBK.
研究一直致力于开发针对传染性牛角膜结膜炎（IBK）的有效疫苗。大多数研究都集中在针对莫拉氏菌属牛种抗原的注射用疫苗上；然而，研究人员也将莫拉氏菌属牛种抗原纳入疫苗中，以预防 IBK。目前仍然存在一些关键的知识空白，例如哪些莫拉氏菌属抗原可能具有完全的保护作用，以及针对与莫拉氏菌属相关的 IBK，是否需要全身免疫反应和黏膜免疫反应。尚未分析对居住在上呼吸道和眼睛中的共生莫拉氏菌属的免疫反应，以确定这些反应是否控制定植或有助于 IBK。
