晚期早产儿应用地塞米松对撤机的影响。
Efficacy of late postnatal dexamethasone on weaning from invasive mechanical ventilation in extreme premature infants.
机构信息
Division of Neonatology, Department of Pediatrics, Children's National Medical Center, Washington, DC, USA.
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, Miami, FL, USA.
出版信息
J Perinatol. 2021 Aug;41(8):1951-1955. doi: 10.1038/s41372-021-01108-4. Epub 2021 May 28.
OBJECTIVE
To evaluate the short-term respiratory effects of PND in a cohort of ventilator-dependent premature infants.
STUDY DESIGN
Clinical data from 106 infants 23-28 weeks gestation who received PND for weaning from MV during 2011-2017 were evaluated. PND was started at a dose of 0.1 mg/kg/d tapered over 5-7 d. Treatment success was defined as extubated and free from MV on d14 after start of treatment.
RESULT
Treatment was successful in 83 (78%) infants. Demographics and age of treatment did not differ between groups. In the failure group, a higher proportion were on HFOV and FiO ≥ 0.50 before treatment, compared to the successful group.
CONCLUSION
In most infants, PND resulted in successful weaning from MV. Reduced need for oxygen in infants not extubated may be beneficial, but it is unknown if this offsets the risks. The long-term effects PND in ventilator dependent infants need to be evaluated.
目的
评估 PND 在一组依赖呼吸机的早产儿中的短期呼吸影响。
研究设计
评估了 2011 年至 2017 年期间因接受 PND 以从 MV 撤机而接受治疗的 106 名 23-28 周龄婴儿的临床数据。PND 的起始剂量为 0.1mg/kg/d，在 5-7 天内逐渐减少。治疗成功定义为治疗开始后第 14 天拔管且不再需要 MV。
结果
83 名（78%）婴儿的治疗成功。治疗组和失败组的人口统计学特征和治疗年龄没有差异。在失败组中，与成功组相比，治疗前需要 HFOV 和 FiO2≥0.50 的比例更高。
结论
在大多数婴儿中，PND 可成功从 MV 撤机。减少未拔管婴儿对氧气的需求可能是有益的，但尚不清楚这是否会抵消风险。需要评估 PND 在依赖呼吸机的婴儿中的长期影响。
Zotero 插件