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合成、结构与性能的碳/碳复合材料人工肋骨用于胸壁重建。

Synthesis, structure, and properties of carbon/carbon composites artificial rib for chest wall reconstruction.

机构信息

State Key Laboratory for Powder Metallurgy, Central South University, Changsha, 410083, Hunan, People's Republic of China.

Hunan Tankang Biotech Co., LTD., Changsha, 410083, Hunan, People's Republic of China.

出版信息

Sci Rep. 2021 May 28;11(1):11285. doi: 10.1038/s41598-021-90951-8.

DOI:10.1038/s41598-021-90951-8
PMID:34050262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8163812/
Abstract

In this work, braided carbon fiber reinforced carbon matrix composites (3D-C/C composites) are prepared by chemical vapor infiltration process. Their composite structure, mechanical properties, biocompatibility, and in vivo experiments are investigated and compared with those of traditional 2.5D-C/C composites and titanium alloys TC4. The results show that 3D-C/C composites are composed of reinforced braided carbon fiber bundles and pyrolytic carbon matrix and provide 51% open pores with a size larger than 100 μm for tissue adhesion and growth. The Young's modulus of 3D-C/C composites is about 5 GPa, much smaller than those of 2.5D-C/C composites and TC4, while close to the autogenous bone. 3D-C/C composites have a higher tensile strength (167 MPa) and larger elongation (5.0%) than 2.5D-C/C composites (81 MPa and 0.7%), and do not show obvious degradation after 1 × 10 cyclic tensile loading. The 3D-C/C composites display good biocompatibility and have almost no artifacts on CT imaging. The in vivo experiment reveals that 3D-C/C composites artificial ribs implanted in dogs do not show displacement or fracture in 1 year, and there are no obvious proliferation and inflammation in the soft tissues around 3D-C/C composites implant. Our findings demonstrate that 3D-C/C composites are suitable for chest wall reconstruction and present great potentials in artificial bones.

摘要

在这项工作中，通过化学气相渗透工艺制备了编织碳纤维增强碳基复合材料（3D-C/C 复合材料）。对其复合材料结构、力学性能、生物相容性以及体内实验进行了研究，并与传统的 2.5D-C/C 复合材料和钛合金 TC4 进行了比较。结果表明，3D-C/C 复合材料由增强的编织碳纤维束和热解碳基体组成，提供了 51%的开放孔隙，其尺寸大于 100μm，有利于组织黏附和生长。3D-C/C 复合材料的杨氏模量约为 5GPa，远小于 2.5D-C/C 复合材料和 TC4，但与自体骨接近。3D-C/C 复合材料的拉伸强度（167MPa）和伸长率（5.0%）高于 2.5D-C/C 复合材料（81MPa 和 0.7%），并且在 1×10 次循环拉伸加载后没有明显的降解。3D-C/C 复合材料具有良好的生物相容性，在 CT 成像中几乎没有伪影。体内实验表明，植入犬体内的 3D-C/C 复合材料人工肋骨在 1 年内没有发生移位或断裂，3D-C/C 复合材料周围的软组织也没有明显的增殖和炎症。我们的研究结果表明，3D-C/C 复合材料适用于胸壁重建，在人工骨方面具有巨大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/ccbd0749dd18/41598_2021_90951_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/1d0a0081b733/41598_2021_90951_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/6950384d750f/41598_2021_90951_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/398db2ffc758/41598_2021_90951_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/7b99669c1952/41598_2021_90951_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/cc834b95b8b8/41598_2021_90951_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/a07c9e937f53/41598_2021_90951_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/ccbd0749dd18/41598_2021_90951_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/1d0a0081b733/41598_2021_90951_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/6950384d750f/41598_2021_90951_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/398db2ffc758/41598_2021_90951_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/7b99669c1952/41598_2021_90951_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/cc834b95b8b8/41598_2021_90951_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/a07c9e937f53/41598_2021_90951_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c890/8163812/ccbd0749dd18/41598_2021_90951_Fig7_HTML.jpg

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