Hawkes Jason E, See Kyoungah, Burge Russel, Strakbein Stephanie, McKean-Matthews Missy, Saure Daniel, Gooderham Melinda, Leonardi Craig
Department of Dermatology, University of California-Davis, Sacramento, CA, USA.
Eli Lilly and Company, Indianapolis, IN, USA.
Dermatol Ther (Heidelb). 2021 Aug;11(4):1107-1118. doi: 10.1007/s13555-021-00548-2. Epub 2021 May 29.
Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A, is an approved treatment for plaque psoriasis. This study aimed to use animated visualizations as a tool to simplify complex data from ixekizumab clinical trials.
Animated visualizations were developed to show outcomes from ixekizumab clinical trials and a Bayesian network meta-analysis of 11 approved biologics. The visualizations simultaneously highlighted both aggregate scores and the individual progression of patients over the course of treatment.
The animations provided key messages and information from the complex data in efficient and scientific ways that were also visually pleasing and simple to understand. The animations highlighted (1) rapid reduction in disease severity from baseline; (2) sustained efficacy of ixekizumab in the treatment of skin and nail psoriasis; (3) side-by-side comparisons of treatment efficacy and clinical improvement across trials; (4) simultaneous visual presentation of individual results with summary response over time; and (5) indirect comparison of relative treatment effects with other biologics based on Bayesian network meta-analysis.
The rapid and sustained efficacy of ixekizumab in the treatment of psoriasis was demonstrated using multiple dynamic visualizations with different clinical endpoints. Animated visualizations provided a simpler and more comprehensive understanding of complex data than conventional static figures.
司库奇尤单抗是一种高亲和力单克隆抗体，可选择性靶向白细胞介素-17A，是一种已获批的斑块状银屑病治疗药物。本研究旨在使用动态可视化作为工具，简化司库奇尤单抗临床试验中的复杂数据。
开发动态可视化以展示司库奇尤单抗临床试验的结果以及对11种已获批生物制剂的贝叶斯网络荟萃分析结果。这些可视化同时突出了治疗过程中的总体评分和患者的个体进展情况。
这些动画以高效且科学的方式呈现了复杂数据中的关键信息，视觉效果良好且易于理解。这些动画突出了以下几点：（1）疾病严重程度相对于基线的快速降低；（2）司库奇尤单抗在治疗皮肤和指甲银屑病方面的持续疗效；（3）各试验之间治疗效果和临床改善情况的并列比较；（4）随着时间推移，个体结果与总体反应的同时可视化呈现；（5）基于贝叶斯网络荟萃分析，与其他生物制剂相对治疗效果的间接比较。
使用具有不同临床终点的多种动态可视化展示了司库奇尤单抗治疗银屑病的快速和持续疗效。与传统静态图表相比，动态可视化能让人更简单、更全面地理解复杂数据。
