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撤稿:恩格列净和新橘皮苷通过 Nrf2/PPARγ/HO-1 信号通路的启动和 NF-κB/Keap1/HSP70/caspase-3 轴的抑制减轻了大鼠甲氨蝶呤的肝毒性。

RETRACTED: Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats.

机构信息

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt.

出版信息

Life Sci. 2021 Aug 1;278:119638. doi: 10.1016/j.lfs.2021.119638. Epub 2021 May 27.

DOI:10.1016/j.lfs.2021.119638
PMID:34051216
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. A reader reported several mistakes in the paper including duplicated images in Figures 9 and 10, incorrect names of primer sequences and reference gene, as well as unclear description of the statistical analysis. The authors requested that a corrigendum be published, however, due to the large number of corrections applied, it cannot be concluded that these changes would not alter the conclusions of the paper. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

摘要

本文已被撤回

请参阅爱思唯尔关于文章撤回的政策(http://www.elsevier.com/locate/withdrawalpolicy)。应主编要求,本文已被撤回。一位读者报告了该论文中的几个错误,包括图 9 和 10 中的重复图像、引物序列和参照基因的错误名称,以及对统计分析的不清晰描述。作者要求发表更正,但由于更正的数量众多,不能确定这些更改不会改变论文的结论。科学界对此事持非常强烈的态度,并向本刊读者道歉,在提交过程中未能发现这一点。

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