Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
Department of Nuclear Physics, Research School of Physics, The Australian National University, Canberra, Australia.
Appl Radiat Isot. 2021 Aug;174:109777. doi: 10.1016/j.apradiso.2021.109777. Epub 2021 May 12.
Auger emitting radioisotopes are of great interest in targeted radiotherapy because, once internalised in the tumour cells, they can deliver dose locally to the radiation sensitive targets, while not affecting surrounding cells. Geant4 is a Monte Carlo code widely used to characterise the physics mechanism at the basis of targeted radiotherapy. In this work, we benchmarked the modelling of the emission of Auger electrons in Geant4 deriving from the decay of I, I, I radionuclides against existing theoretical approaches. We also compared Geant4 against reference data in the case of Cs, which is of interest for brachytherapy. In the case of I and Cs, the simulation results are compared to experimental measurements as well. Good agreement was found between Geant4 and the reference data. As far as we know, this is the first study aimed to benchmark against experimental measurements the emission of Auger electrons in Geant4 for radiotherapy applications.
俄歇发射放射性同位素在靶向放射治疗中非常有意义，因为一旦它们被内化到肿瘤细胞中，就可以将剂量局部递送到辐射敏感的靶标，而不会影响周围的细胞。Geant4 是一种广泛用于描述靶向放射治疗基础物理机制的蒙特卡罗代码。在这项工作中，我们对 Geant4 中源自 I、I、I 放射性核素衰变的俄歇电子发射的建模进行了基准测试，以与现有的理论方法进行比较。我们还比较了 Geant4 在 Cs 的情况下与参考数据的比较，Cs 对近距离治疗很有意义。在 I 和 Cs 的情况下，模拟结果也与实验测量结果进行了比较。Geant4 与参考数据之间存在良好的一致性。据我们所知，这是第一个旨在针对放射治疗应用中的 Geant4 俄歇电子发射进行实验测量基准测试的研究。
