Centre Antoine-Lacassagne, 33, avenue de Valombrose, 06000 Nice, France.
Centre de radiothérapie Bayard, Orlam, 59, avenue Galline, 69100 Villeurbanne, France.
Cancer Radiother. 2021 Dec;25(8):795-800. doi: 10.1016/j.canrad.2021.04.006. Epub 2021 May 26.
The Papillon experience and the Lyon R96-02 trial have shown that contact X-ray brachytherapy of 50kV is efficient and safe to achieve long term local control and organ preservation for cT1 and early cT2-3 rectal cancers. The OPERA trial, using the Papillon 50™ machine, brings further support to this preservation strategy for selected T2T3ab lesions. Future trials using a contact X-ray boost will try to consolidate and enlarge its place in organ preservation for rectal cancers.
Papillon 经验和 Lyon R96-02 试验表明，50kV 接触式 X 射线近距离放疗对于 cT1 和早期 cT2-3 直肠癌可实现长期局部控制和器官保存，疗效确切且安全性良好。OPERA 试验采用 Papillon 50™ 机器，为选择的 T2T3ab 病变提供了进一步支持这种保存策略的证据。未来采用接触式 X 射线推量照射的试验将尝试巩固和扩大其在直肠癌器官保存中的地位。
