Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Office E6133, Baltimore, MD, USA.
Department of Epidemiology & Population Health, School of Public Health & Information Sciences, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Breast Cancer Res Treat. 2021 Aug;189(1):247-256. doi: 10.1007/s10549-021-06261-0. Epub 2021 May 29.
To explore the relationship between physical activity (PA) and quality of life (QOL) among Hispanic and non-Hispanic white breast cancer (BC) cases and population-based controls from the New Mexico 'Long-Term Quality of Life Study'.
Self-reported PA (low, moderate, vigorous MET hours/week) at baseline and follow-up interviews (12-15 years) were available for 391 cases and controls and modeled using multiple linear regressions with SF-36 mean composite scores for physical and mental health. The change in PA from baseline to follow-up and interactions with ethnicity were also examined. Models were adjusted for age at diagnosis/baseline interview, education, comorbidities, body mass index, and change in PA.
PA intensities at each timepoint did not differ by case/control status; however, the change in vigorous PA was lower among cases (p = 0.03). At follow-up, low intensity PA increased mental health QOL scores among cases; however, the interaction between low intensity PA and ethnicity was statistically significant among controls indicating decreased mental health among Hispanics (p = 0.02). Change in moderate PA was associated with increased physical and mental health among cases (physical: β = 0.186, p = 0.008; mental: β = 0.225, p = 0.001) and controls (physical: β = 0.220, p < 0.0001; mental: β = 0.193, p = 0.002), when controlling for confounders.
Our results demonstrate that all levels of PA are important for mental health among BC cases, while activities of higher intensity are important for physical health among women overall. The statistical interaction observed between ethnicity and low intensity PA among controls for mental health warrants further research to provide a meaningful interpretation.
探讨新墨西哥州“长期生活质量研究”中西班牙裔和非西班牙裔白人乳腺癌（BC）病例和基于人群的对照者的体力活动（PA）与生活质量（QOL）之间的关系。
391 例病例和对照者在基线和随访访谈（12-15 年）时可获得自我报告的 PA（低、中、高强度 MET 小时/周），并使用 SF-36 心理健康和身体健康综合平均评分的多线性回归进行建模。还检查了从基线到随访的 PA 变化以及与种族的交互作用。模型调整了诊断/基线访谈时的年龄、教育程度、合并症、体重指数和 PA 的变化。
每个时间点的 PA 强度不因病例/对照状态而异；然而，病例组剧烈 PA 的变化较低（p=0.03）。在随访时，低强度 PA 增加了病例的心理健康 QOL 评分；然而，低强度 PA 与种族之间的交互作用在对照组中具有统计学意义，表明西班牙裔人的心理健康状况下降（p=0.02）。中度 PA 的变化与病例和对照组的身体健康和心理健康均相关（身体：β=0.186，p=0.008；心理：β=0.225，p=0.001），在控制混杂因素后。
我们的结果表明，所有水平的 PA 对 BC 病例的心理健康都很重要，而高强度的活动对女性整体的身体健康很重要。在对照组中观察到的种族和低强度 PA 之间的统计学交互作用需要进一步研究，以提供有意义的解释。
