情绪的膜分子。

Membrane molecules for mood.

机构信息

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt am Main, Germany.

Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland.

出版信息

Trends Neurosci. 2021 Aug;44(8):602-604. doi: 10.1016/j.tins.2021.05.001. Epub 2021 May 27.

DOI:10.1016/j.tins.2021.05.001

PMID:34053679

Abstract

According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.

摘要

根据抑郁症的数十年历史的神经营养假说，抗抑郁药的延迟作用据称是由于它们对神经元可塑性的下游影响。在最近的一项研究中，Casarotto 等人发现，抗抑郁药实际上可以直接与神经营养因子 TRKB 受体结合，并通过这种机制发挥作用。