Department of Medicine, Dhaka Medical College Hospital, Secretariat Road, Dhaka 1000, Bangladesh.
Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
Crit Care Clin. 2021 Jul;37(3):673-686. doi: 10.1016/j.ccc.2021.03.011.
Organophosphorus (OP) compounds remain a leading cause of self-poisoning and mortality, especially in South East Asia, China, and Africa. Organophosphorus causes an acute cholinergic syndrome by inhibiting acetylcholinesterase. Atropine remains the mainstay of treatment, but recently some promising therapies are in the pipeline. Oximes are used widely in the management of organophosphorus poisoning, however clinical efficacy remains to be established. Magnesium sulfate, calcium channel blockers (nimodipine), plasma alkalinizing agents, β-2 agonists, nicotinic receptor antagonists, clonidine, and lipid emulsions are promising treatment alternatives. However, large phase III trials are required to establish their efficacy.
有机磷（OP）化合物仍然是自我中毒和死亡的主要原因，特别是在东南亚、中国和非洲。有机磷通过抑制乙酰胆碱酯酶引起急性胆碱能综合征。阿托品仍然是治疗的主要方法，但最近有一些有前途的治疗方法正在研发中。肟类化合物广泛用于有机磷中毒的治疗，但临床疗效仍有待确定。硫酸镁、钙通道阻滞剂（尼莫地平）、血浆碱化剂、β-2 激动剂、烟碱受体拮抗剂、可乐定和脂肪乳剂是有前途的治疗替代品。然而，需要进行大规模的 III 期临床试验来确定它们的疗效。
