急性脊髓损伤的低温疗法。
Hypothermia for Acute Spinal Cord Injury.
机构信息
Department of Neurological Surgery, University of Miami MILLER School of Medicine, Lois Pope Life Center, 1095 Northwest 14th Terrace, Suite 2-24, Miami, FL 33136, USA.
Department of Neurological Surgery, University of Miami MILLER School of Medicine, Lois Pope Life Center, 1095 Northwest 14th Terrace, Suite 2-24, Miami, FL 33136, USA.
出版信息
Neurosurg Clin N Am. 2021 Jul;32(3):377-387. doi: 10.1016/j.nec.2021.03.009.
Neuroprotection after acute spinal cord injury is an important strategy to limit secondary injury. Animal studies have shown that systemic hypothermia is an effective neuroprotective strategy that can be combined with other therapies. Systemic hypothermia affects several processes at the cellular level to reduce metabolic activity, oxidative stress, and apoptotic neuronal cell death. Modest systemic hypothermia has been shown to be safe and feasible in the acute phase after cervical spinal cord injury. These data have provided the impetus for an active multicenter randomized controlled trial for modest systemic hypothermia in acute cervical spinal cord injury.
急性脊髓损伤后的神经保护是限制继发损伤的重要策略。动物研究表明，全身低温是一种有效的神经保护策略，可以与其他治疗方法结合使用。全身低温会在细胞水平上影响多个过程，以降低代谢活动、氧化应激和凋亡性神经元细胞死亡。适度的全身低温已被证明在颈脊髓损伤后的急性期是安全且可行的。这些数据为急性颈脊髓损伤中适度全身低温的多中心随机对照试验提供了动力。
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