Dietrich William Dalton, Cappuccino Andrew, Cappuccino Helen
The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Curr Sports Med Rep. 2011 Jan-Feb;10(1):50-4. doi: 10.1249/JSR.0b013e318205e0b3.
Spinal cord injury is a devastating condition that affects approximately 12,000 patients each year in the United States. Major causes for spinal cord injury include motor vehicle accidents, sports-related injuries, and direct trauma. Moderate hypothermia has gained attention as a potential therapy due to recent experimental and clinical studies and the use of modest systemic hypothermia (MSH) in high profile case of spinal cord injury in a National Football League (NFL) player. In experimental models of spinal cord injury, moderate hypothermia has been shown to improve functional recovery and reduce overall structural damage. In a recent Phase I clinical trial, systemic hypothermia has been shown to be safe and provide some encouraging results in terms of functional recovery. This review will summarize recent preclinical data, as well as clinical findings that support the continued investigations for the use of hypothermia in severe cervical spinal cord injury.
脊髓损伤是一种严重的疾病，在美国每年约影响12000名患者。脊髓损伤的主要原因包括机动车事故、与运动相关的损伤和直接创伤。由于最近的实验和临床研究，以及在一名美国国家橄榄球联盟（NFL）球员的备受瞩目的脊髓损伤病例中使用适度全身低温（MSH），适度低温作为一种潜在的治疗方法受到了关注。在脊髓损伤的实验模型中，适度低温已被证明可改善功能恢复并减少整体结构损伤。在最近的一项I期临床试验中，全身低温已被证明是安全的，并在功能恢复方面提供了一些令人鼓舞的结果。本综述将总结近期临床前数据以及临床研究结果，这些数据和结果支持继续研究低温在严重颈脊髓损伤中的应用。
