Browning Craig M, Mayes Samuel, Favreau Peter, Rich Thomas C, Leavesley Silas J
Chemical and Biomolecular Engineering, University of South Alabama, AL 36688.
Pharmacology, University of South Alabama, AL 36688.
Proc SPIE Int Soc Opt Eng. 2016 Feb;9703. doi: 10.1117/12.2213200. Epub 2016 Mar 7.
Colorectal cancer is the United States 3rd leading cancer in death rates. The current screening for colorectal cancer is an endoscopic procedure using white light endoscopy (WLE). There are multiple new methods testing to replace WLE, for example narrow band imaging and autofluorescence imaging. However, these methods do not meet the need for a higher specificity or sensitivity. The goal for this project is to modify the presently used endoscope light source to house 16 narrow wavelength LEDs for spectral imaging in real time while increasing sensitivity and specificity. The process to do such was to take an Olympus CLK-4 light source, replace the light and electronics with 16 LEDs and new circuitry. This allows control of the power and intensity of the LEDs. This required a larger enclosure to house a bracket system for the solid light guide (lightpipe), three new circuit boards, a power source and National Instruments hardware/software for computer control. The results were a successfully designed retrofit with all the new features. The LED testing resulted in the ability to control each wavelength's intensity. The measured intensity over the voltage range will provide the information needed to couple the camera for imaging. Overall the project was successful; the modifications to the light source added the controllable LEDs. This brings the research one step closer to the main goal of spectral imaging for early detection of colorectal cancer. Future goals will be to connect the camera and test the imaging process.
结直肠癌是美国死亡率排名第三的癌症。目前结直肠癌的筛查是一种使用白光内镜检查（WLE）的内镜检查程序。有多种新方法正在测试以取代WLE，例如窄带成像和自体荧光成像。然而，这些方法并不满足对更高特异性或敏感性的需求。该项目的目标是对目前使用的内窥镜光源进行改造，以容纳16个窄波长发光二极管用于实时光谱成像，同时提高敏感性和特异性。进行此项工作的过程是采用一台奥林巴斯CLK - 4光源，用16个发光二极管和新电路替换其灯光和电子元件。这使得能够控制发光二极管的功率和强度。这需要一个更大的外壳来容纳用于固体光导（光管）的支架系统、三块新电路板、一个电源以及用于计算机控制的美国国家仪器公司的硬件/软件。结果是成功设计出了具备所有新特性的改装设备。对发光二极管的测试实现了对每个波长强度的控制。在电压范围内测量的强度将提供为耦合相机进行成像所需的信息。总体而言，该项目取得了成功；对光源的改造增加了可控发光二极管。这使该研究朝着用于结直肠癌早期检测的光谱成像这一主要目标又迈进了一步。未来的目标将是连接相机并测试成像过程。
