该基因中的rs1634330多态性与有男性后代的中国核心家庭的身体组成相关。
The rs1634330 Polymorphisms in the Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring.
作者信息
Qi Luyue, Liu Lianyong, Li Li, Hu Weiwei, Fu Wenzhen, Hu Ji, Xu Youjia, Zhang Zhenlin
机构信息
Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai 200233, China.
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
出版信息
Int J Endocrinol. 2021 May 8;2021:6698822. doi: 10.1155/2021/6698822. eCollection 2021.
OBJECTIVE
The purpose of this study was to explore the effect of the gene polymorphisms on body composition in Chinese nuclear families with male offspring.
METHODS
1,016 individuals were recruited from 335 Chinese nuclear families with male offspring. The nuclear families consist of at least one male offspring aged 18 to 44. We genotyped the 10 tagged single-nucleotide polymorphisms (SNPs) in gene (rs7220711, rs865429, rs851057, rs1708635, rs2023794, rs1234612, rs74252774, rs1634330, rs851058, and rs1513670) in all the above people. We used dual-energy X-ray absorptiometry to measure the composition of the human body. The quantitative transmission disequilibrium test (QTDT) was used to analyze the associations of the SNPs with the body composition.
RESULTS
QTDT analysis showed that rs1634330 was significantly associated with trunk LM ( < 0.05). However, haplotypes were not found to be significantly associated with the body composition in the within-family association. The 1000 permutations were consistent with these within-family association results.
CONCLUSIONS
Our results showed that the genetic variation in the gene may contribute to variations in the body composition of Chinese male offspring.
目的
本研究旨在探讨基因多态性对有男性后代的中国核心家庭身体组成的影响。
方法
从335个有男性后代的中国核心家庭中招募了1016名个体。这些核心家庭至少有一名年龄在18至44岁之间的男性后代。我们对上述所有人的基因中的10个标签单核苷酸多态性（SNP）进行了基因分型（rs7220711、rs865429、rs851057、rs1708635、rs2023794、rs1234612、rs74252774、rs1634330、rs851058和rs1513670）。我们使用双能X射线吸收法测量人体组成。采用定量传递不平衡检验（QTDT）分析SNP与身体组成的关联。
结果
QTDT分析显示，rs1634330与躯干瘦体重显著相关（P<0.05）。然而，在家庭内关联中未发现单倍型与身体组成有显著关联。1000次置换与这些家庭内关联结果一致。
结论
我们的结果表明，该基因的遗传变异可能导致中国男性后代身体组成的差异。
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