Wang Yaxin, Zhang Huicun, Wang Hongbing
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China.
Evid Based Complement Alternat Med. 2021 May 11;2021:5569274. doi: 10.1155/2021/5569274. eCollection 2021.
Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.
骨髓间充质干细胞移植作为一种治疗肝脏疾病的再生疗法,已受到越来越多的关注。大量研究表明,这类细胞可通过多种方式抑制肝星状细胞的激活,并调节组织稳态和免疫系统。同时,骨髓间充质干细胞可通过多种途径抑制肝细胞凋亡、改善肝功能并减轻炎症。这些细胞在肝硬化治疗方面具有广阔前景。目前,关于骨髓间充质干细胞移植治疗肝硬化的具体机制有很多研究。本文综述了肝硬化的发病机制以及骨髓间充质干细胞移植治疗肝硬化的机制,探讨了中医方法在增强骨髓间充质干细胞移植疗效方面的作用,并展望了其未来的应用前景。