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本文引用的文献

1
Biostimulative effect of laser on growth of mesenchymal stem/stromal cells .激光对间充质干/基质细胞生长的生物刺激作用
Postepy Dermatol Alergol. 2020 Oct;37(5):771-780. doi: 10.5114/ada.2020.100487. Epub 2020 Nov 7.
2
Induction of the differentiation of porcine bone marrow mesenchymal stem cells into premature hepatocyte-like cells in an indirect coculture system with primary hepatocytes.在与原代肝细胞的间接共培养系统中诱导猪骨髓间充质干细胞分化为早熟肝细胞样细胞。
Anim Cells Syst (Seoul). 2020 Oct 4;24(5):289-298. doi: 10.1080/19768354.2020.1823473.
3
Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes.慢性乙型肝炎患者的肝硬化与DNA修复途径基因的遗传变异有关。
Cancers (Basel). 2020 Nov 7;12(11):3295. doi: 10.3390/cancers12113295.
4
In utero xenotransplantation of mice bone marrow-derived stromal/stem cells into fetal rat liver: An experimental study.小鼠骨髓源基质/干细胞宫内异种移植至胎鼠肝脏的实验研究
Int J Reprod Biomed. 2020 Sep 20;18(9):701-712. doi: 10.18502/ijrm.v13i9.7665. eCollection 2020 Sep.
5
The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future.间充质干细胞在肝脏疾病中的临床应用：现状与未来潜力
Ann Transl Med. 2020 Apr;8(8):565. doi: 10.21037/atm.2020.03.218.
6
Immunomodulatory properties of bone marrow mesenchymal stem cells.骨髓间充质干细胞的免疫调节特性
J Biosci. 2020;45.
7
Changes of immune parameters of T lymphocytes and macrophages in EAE mice after BM-MSCs transplantation.骨髓间充质干细胞移植后 EAE 小鼠 T 淋巴细胞和巨噬细胞免疫参数的变化。
Immunol Lett. 2020 Sep;225:66-73. doi: 10.1016/j.imlet.2020.05.005. Epub 2020 Jun 13.
8
In a Rat Model of Acute Liver Failure, Icaritin Improved the Therapeutic Effect of Mesenchymal Stem Cells by Activation of the Hepatocyte Growth Factor/c-Met Pathway.在急性肝衰竭大鼠模型中，淫羊藿素通过激活肝细胞生长因子/c-Met通路提高了间充质干细胞的治疗效果。
Evid Based Complement Alternat Med. 2019 Nov 7;2019:4253846. doi: 10.1155/2019/4253846. eCollection 2019.
9
Bone marrow-derived mesenchymal stem cell (BM-MSC): A tool of cell therapy in hydatid experimentally infected rats.骨髓间充质干细胞（BM-MSC）：实验性感染包虫的大鼠细胞治疗工具。
Cell Regen. 2019 Nov 21;8(2):58-71. doi: 10.1016/j.cr.2019.11.001. eCollection 2019 Dec.
10
Bone Marrow-Derived Mesenchymal Stem Cell Potential Regression of Dysplasia Associating Experimental Liver Fibrosis in Albino Rats.骨髓间充质干细胞对实验性肝纤维化大鼠肝发育不良的潜在逆转作用。
Biomed Res Int. 2019 Nov 6;2019:5376165. doi: 10.1155/2019/5376165. eCollection 2019.

中药对骨髓间充质干细胞治疗肝硬化干预作用的研究进展

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells.

作者信息

Wang Yaxin, Zhang Huicun, Wang Hongbing

机构信息

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.

Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China.

出版信息

Evid Based Complement Alternat Med. 2021 May 11;2021:5569274. doi: 10.1155/2021/5569274. eCollection 2021.

DOI:10.1155/2021/5569274
PMID:34055009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8131131/
Abstract

Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

摘要

骨髓间充质干细胞移植作为一种治疗肝脏疾病的再生疗法，已受到越来越多的关注。大量研究表明，这类细胞可通过多种方式抑制肝星状细胞的激活，并调节组织稳态和免疫系统。同时，骨髓间充质干细胞可通过多种途径抑制肝细胞凋亡、改善肝功能并减轻炎症。这些细胞在肝硬化治疗方面具有广阔前景。目前，关于骨髓间充质干细胞移植治疗肝硬化的具体机制有很多研究。本文综述了肝硬化的发病机制以及骨髓间充质干细胞移植治疗肝硬化的机制，探讨了中医方法在增强骨髓间充质干细胞移植疗效方面的作用，并展望了其未来的应用前景。