Chalhoub Sabine, Yaghi Marita, Ard Natasha, Kanso Mariam, Allam Jad, Khalife Mohamad, Jaafar Rola F, Faraj Walid
Department of General Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
Sleep Disord. 2021 May 4;2021:5535220. doi: 10.1155/2021/5535220. eCollection 2021.
Sleep disturbances are more common in cancer patients than in the general population; however, there is limited research pertaining to the occurrence of such disturbances that subsequently impact patients' quality of life. The aim of our study is to describe the prevalence of insomnia among pancreatic cancer patients who have recently undergone recent pancreaticoduodenectomy.
We performed a 6-year (2014-2020) retrospective cohort analysis of all adult patients aged 18 and above with pancreatic cancer who underwent pancreaticoduodenectomy at our institution. Insomnia was characterized using the Pittsburgh Sleep Quality Index (PSQI). Symptoms of insomnia and the impact caused by these symptoms on daily lives were assessed with the Insomnia Severity Index (ISI), and patients were divided into mild insomnia (ISI 8-14) or moderate to severe insomnia (ISI ≥ 15).
Out of forty patients with pancreatic cancer that have undergone pancreaticoduodenectomy, 19 (47.2%) reported that their sleep disturbances had a significant effect on their quality of life. A total of 22 (55.0%) patients reported insomnia, with 63.2% reporting mild insomnia. Chemotherapy was found to significantly increase the risk of moderate to severe insomnia. The mean ISI score was 7.2 ± 6.9, and the mean PSQI score was 7.0 ± 5.1. ISI and PSQI showed a strong positive correlation ( = 0.78, < 0.01).
Sleep disturbances such as insomnia following pancreatic cancer surgery are highly prevalent. Treating physicians and surgeons should recognize and routinely screen for sleep disorders through the management of a multidisciplinary team in order to alleviate some of the burden on the patients' mental well-being.
睡眠障碍在癌症患者中比在普通人群中更为常见；然而，关于此类障碍的发生及其对患者生活质量产生影响的研究有限。我们研究的目的是描述近期接受胰十二指肠切除术的胰腺癌患者中失眠的患病率。
我们对在我院接受胰十二指肠切除术的所有18岁及以上的成年胰腺癌患者进行了为期6年（2014 - 2020年）的回顾性队列分析。使用匹兹堡睡眠质量指数（PSQI）来表征失眠。采用失眠严重程度指数（ISI）评估失眠症状及其对日常生活造成的影响，患者被分为轻度失眠（ISI 8 - 14）或中度至重度失眠（ISI≥15）。
在40例接受胰十二指肠切除术的胰腺癌患者中，19例（47.2%）报告其睡眠障碍对生活质量有显著影响。共有22例（55.0%）患者报告有失眠，其中63.2%报告为轻度失眠。发现化疗会显著增加中度至重度失眠的风险。ISI平均评分为7.2±6.9，PSQI平均评分为7.0±5.1。ISI与PSQI呈强正相关（ = 0.78，<0.01）。
胰腺癌手术后的失眠等睡眠障碍非常普遍。治疗医生和外科医生应认识到这一点，并通过多学科团队的管理对睡眠障碍进行常规筛查，以减轻患者心理健康方面的一些负担。
