Avdulla Christos S, Papadas Theodoros, Mastronikolis Nicholas, Jelastopulu Eleni
Department of Public Health, University of Patras, Patras, GRC.
Department of Otorhinolaryngology, University of Patras, Patras, GRC.
Cureus. 2021 Apr 27;13(4):e14711. doi: 10.7759/cureus.14711.
Purpose The purpose of this study is to assess the overall survival (OS) of patients with nasopharyngeal cancer and the factors affecting the survival rates. Methods A retrospective cohort study was performed, including 77 patients with nasopharyngeal cancer diagnosed and treated in the Otorhinolaryngology Clinic of the University Hospital of Patras during 1990-2017. The prognostic impact of age, gender, occupation, smoking/alcohol, and TNM staging were evaluated using Kaplan-Meier analysis. Results During the last 28 years, nasopharyngeal cancer (NPC) was higher in men (80.5% of patients) than women (19.5%) (mean age 56-years). Most patients were smokers (64.9%, mean 70 pack-years) and 35 (45.5%) of them were alcohol users. Postoperative staging indicated 39% stage-III, 26% stage-IV, and 26% stage-I. Histologically, 70.1% of the volumes were WHO-III, 20.8% WHO-II, and 5.2% WHO-I. Also, 98.7% of patients received radiotherapy, 85.7% chemotherapy, and 20.8% surgery. More than half were farmers (26%), self-employed (16.9%), and workers (14.3). During the follow-up (mean 66 months), 38 (49.5%) patients died, 88.9% from disease-related causes. The 5-year survival was 58.8%, 74.5% for non-smokers, and 49.1% for smokers, and 10-year survival was 43.6%, 63.4%, and 31.6%, respectively (p=0.016). Moreover, significant statistical differences were observed in age (p=0.054), time period of diagnosis and treatment (p=0.002), cause of death (p=0.033), and metastatic disease (p=0.023). Conclusions Age, stage in disease detection, tumor characteristics, treatment, and tobacco abuse are important factors that affect the OS of patients with NPC during the three last decades.
目的 本研究旨在评估鼻咽癌患者的总生存期（OS）以及影响生存率的因素。方法 进行了一项回顾性队列研究，纳入了1990年至2017年期间在帕特雷大学医院耳鼻喉科门诊诊断和治疗的77例鼻咽癌患者。使用Kaplan-Meier分析评估年龄、性别、职业、吸烟/饮酒情况以及TNM分期的预后影响。结果 在过去28年中，男性鼻咽癌（NPC）患者（占患者的80.5%）高于女性（19.5%）（平均年龄56岁）。大多数患者吸烟（64.9%，平均70包年），其中35例（45.5%）饮酒。术后分期显示III期占39%，IV期占26%，I期占26%。组织学上，70.1%的病例为WHO-III级，20.8%为WHO-II级，5.2%为WHO-I级。此外，98.7%的患者接受了放疗，85.7%接受了化疗，20.8%接受了手术。超过一半的患者是农民（26%）、个体经营者（16.9%）和工人（14.3%）。在随访期间（平均66个月），38例（49.5%）患者死亡，88.9%死于疾病相关原因。5年生存率为58.8%，非吸烟者为74.5%，吸烟者为49.1%，10年生存率分别为43.6%、63.4%和31.6%（p=0.016）。此外，在年龄（p=0.054）、诊断和治疗时间段（p=0.002）、死亡原因（p=0.033）和转移性疾病（p=0.023）方面观察到显著的统计学差异。结论 在过去三十年中，年龄、疾病检测阶段、肿瘤特征、治疗以及烟草滥用是影响鼻咽癌患者总生存期的重要因素。
