Raad Tala, George Elena, Griffin Anne, Larkin Louise, Fraser Alexander, Kennedy Norelee, Tierney Audrey
Discipline of Dietetics, School of Allied Health, Faculty of Education and Health Sciences and Health Implementation Science and Technology Centre, Health Research Institute, University of Limerick, Limerick, Ireland.
Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, Victoria, 3220, Australia.
HRB Open Res. 2020 Oct 2;3:72. doi: 10.12688/hrbopenres.13136.1. eCollection 2020.
Rheumatoid arthritis (RA) is an autoimmune disease characterised by swollen and painful joints. It is hypothesised that changes in lifestyle factors such as consuming a healthier diet may reduce the severity of RA symptoms. People living with RA commonly make alterations to their dietary intake with the hope of improving their symptoms. This systematic review aims to discuss the effects of dietary interventions with and without omega-3 supplementation for the management of rheumatoid arthritis. A systematic review of randomised controlled trials (RCTs) and non-randomised controlled trials (NRCTs) will be conducted. MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register) and CINAHL will be searched from inception without using date restrictions. Primary outcomes will include measures of disease activity, inflammation and quality of life among adults living with RA. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the methodological appraisal of the studies will be assessed independently by two different reviewers (TR and AG) using the Cochrane Risk-of-Bias Tool for RCTs, and Risk-of-Bias In Non-Randomised Studies Tool for NRCTs. Ethical approval is not required for this systematic review. Only publically available data from previously published studies will be used. The findings of this systematic review will be submitted for publication in a peer-reviewed journal and presented at relevant conferences. CRD42020147415 (11/02/2020).
类风湿性关节炎（RA）是一种自身免疫性疾病，其特征为关节肿胀和疼痛。据推测，生活方式因素的改变，如采用更健康的饮食，可能会减轻类风湿性关节炎症状的严重程度。患有类风湿性关节炎的人通常会改变饮食摄入量，希望改善症状。本系统评价旨在探讨饮食干预（无论是否补充ω-3）对类风湿性关节炎管理的影响。将对随机对照试验（RCT）和非随机对照试验（NRCT）进行系统评价。将从创刊号开始搜索MEDLINE、EMBASE、Cochrane图书馆（Cochrane系统评价数据库、Cochrane对照试验中央注册库（CENTRAL）、Cochrane方法学注册库）和CINAHL，不设日期限制。主要结局将包括成年类风湿性关节炎患者的疾病活动度、炎症和生活质量指标。研究选择将遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，研究的方法学评价将由两名不同的评审员（TR和AG）使用Cochrane随机对照试验偏倚风险工具和非随机研究偏倚风险工具独立评估。本系统评价无需伦理批准。仅使用先前发表研究中的公开可用数据。本系统评价的结果将提交至同行评审期刊发表，并在相关会议上展示。CRD42020147415（2020年2月11日）
