Khanna Shweta, Jaiswal Kumar Sagar, Gupta Bhawna
Disease Biology Laboratory, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
Front Nutr. 2017 Nov 8;4:52. doi: 10.3389/fnut.2017.00052. eCollection 2017.
Self-help by means of dietary interventions can help in management of various disorders including rheumatoid arthritis (RA), a debilitating autoimmune disease. Dietary interventions necessitate a widespread appeal for both patients as well as clinicians due to factors including affordability, accessibility, and presence of scientific evidences that demonstrate substantial benefits in reducing disease symptoms such as pain, joint stiffness, swelling, tenderness and associated disability with disease progression. However, there is still an uncertainty among the community about the therapeutic benefits of dietary manipulations for RA. In the present review, we provide an account of different diets and their possible molecular mechanism of actions inducing observed therapeutic benefits for remission and management of RA. We further indicate food that can be a potential aggravating factor for the disease or may help in symptomatic relief. We thereafter summarize and thereby discuss various diets and food which help in reducing levels of inflammatory cytokines in RA patients that may play an effective role in management of RA following proper patient awareness. We thus would like to promote diet management as a tool that can both supplement and complement present treatment strategies for a better patient health and recovery.
通过饮食干预进行自我帮助有助于管理包括类风湿性关节炎（RA）在内的各种疾病，RA是一种使人衰弱的自身免疫性疾病。由于包括可承受性、可及性以及存在科学证据表明其在减轻疾病症状（如疼痛、关节僵硬、肿胀、压痛以及疾病进展相关的残疾）方面具有显著益处等因素，饮食干预对患者和临床医生都具有广泛的吸引力。然而，对于饮食调控对RA的治疗益处，该领域仍存在不确定性。在本综述中，我们阐述了不同的饮食及其诱导观察到的RA缓解和管理治疗益处的可能分子作用机制。我们还指出了可能是该疾病潜在加重因素或有助于缓解症状的食物。此后，我们总结并讨论了各种有助于降低RA患者炎症细胞因子水平的饮食和食物，在患者充分了解的情况下，这些可能在RA的管理中发挥有效作用。因此，我们希望推广饮食管理这一工具，它既能补充又能完善当前的治疗策略，以实现更好的患者健康和康复。
