Univ. Lille, CNRS, Centrale Lille, UMR 9013- LaMcube - Laboratoire de Mécanique, Multiphysique, Multi-échelle, F-59000, Lille, France.
Service de Chirurgie gynécologique - CHU Lille, F-59000, Lille, France; Université de Lille - Faculté de Lille, F-59000, Lille, France.
J Mech Behav Biomed Mater. 2021 Aug;120:104569. doi: 10.1016/j.jmbbm.2021.104569. Epub 2021 May 23.
Implants for the cure of female genital prolapse still show numerous complications cases that sometimes have dramatic consequences. These implants must be improved to provide physiological support and restore the normal functionalities of the pelvic area. Besides the trend towards lighter meshes, a better understanding of the in vivo role and impact of the mesh implantation is required. This work investigates the mechanical impact of meshes after implantation with regards to the behavior of the native tissues. Three meshes were studied to assess their mechanical and biological impact on the native tissues. An animal study was conducted on rats. Four groups (n = 17/group) underwent surgery. Rats were implanted on the abdominal wall with one of the three polypropylene knitted mesh (one mesh/group). The last group served as control and underwent the same surgery without any mesh implantation. Post-operative complications, contraction, mechanical rigidities, and residual deformation after cyclic loading were collected. Non-parametric statistical comparisons were performed (Kruskal-Wallis) to observe potential differences between implanted and control groups. Mechanical characterization showed that one of the three meshes did not alter the mechanical behavior of the native tissues. On the contrary, the two others drastically increased the rigidities and were also associated with clinical complications. All of the meshes seem to reduce the geometrical lengthening of the biological tissues that comes with repetitive loads. Mechanical aspects might play a key role in the compatibility of the mesh in vivo. One of the three materials that were implanted during an animal study seems to provide better support and adapt more properly to the physiological behavior of the native tissues.
用于治疗女性生殖器脱垂的植入物仍存在许多并发症，有时会产生严重后果。这些植入物必须加以改进，以提供生理支撑并恢复骨盆区域的正常功能。除了向更轻的网片发展的趋势外，还需要更好地了解网片植入物的体内作用和影响。这项工作研究了植入物后的网片对天然组织行为的机械影响。研究了三种网片，以评估它们对天然组织的机械和生物学影响。在大鼠中进行了动物研究。四个组（n = 17/组）接受了手术。用三种聚丙烯针织网片之一（每组一个网片）在大鼠的腹壁上进行了植入。最后一组作为对照，进行了相同的手术，但没有植入任何网片。收集了术后并发症、收缩、机械硬度和循环加载后的残余变形。进行了非参数统计比较（Kruskal-Wallis），以观察植入组和对照组之间可能存在的差异。力学特性表明，三种网片中的一种没有改变天然组织的力学行为。相反，另外两种网片极大地增加了硬度，并且还与临床并发症相关。所有网片似乎都减少了生物组织在重复负载下的几何伸长。力学方面可能在网片的体内相容性中起着关键作用。在动物研究中植入的三种材料之一似乎提供了更好的支撑，并更适当地适应了天然组织的生理行为。
